鼠李糖乳杆菌GG在结直肠癌中的研究进展

Advances in Research on Lactobacillus rhamnosus GG in Colorectal Cancer

结直肠癌是一种发生于结直肠黏膜上皮的恶性肿瘤,发病率和死亡率在全球恶性肿瘤中位居前列。益生菌是一类对宿主有益的活性微生物,可通过与病原菌竞争、破坏潜在致癌物、减少微生物遗传毒性、增强肠道屏障和宿主固有免疫、调节细胞增殖和凋亡等多种机制降低恶性肿瘤的发生风险。鼠李糖乳杆菌GG(LGG)是研究最早和最广泛的益生菌之一,其通过调节肠道菌群、抗炎、抗增殖以及促凋亡等多种机制在癌症三级预防中展现了巨大的应用潜力。本文就LGG在结直肠癌中的研究进展作一综述。

Colorectal cancer is a kind of malignant tumor that occurs in colorectal mucosal epithelium. Its morbidity and mortality are of the leading rank in the world. Probiotics are active microorganisms beneficial to the host, which can reduce the risk of malignant tumor by competing with pathogens, destroying potential carcinogens, reducing microbial genotoxicity, enhancing intestinal barrier and host innate immunity, regulating cell proliferation and apoptosis and other mechanisms. Lactobacillus rhamnosus GG (LGG) is one of the earliest and most widely studied probiotics, which has shown great potential in the tertiary prevention of cancer by regulating intestinal flora, anti-inflammatory, anti-proliferative and pro-apoptotic mechanisms. This article reviewed the advances in research on LGG in colorectal cancer.