血浆内脏脂肪素与非酒精性脂肪性肝病患者胰岛素抵抗的关系

The Relationship Between Plasma Visceral Fat and Insulin Resistance in Patients with Non-alcoholic Fatty Liver Disease

目的探讨血浆内脏脂肪素与非酒精性脂肪性肝病(NAFLD)患者胰岛素抵抗的关系。方法选取2013年7月~2014年12月于柳州市人民医院非酒精性脂肪性肝病患者110例,根据严重程度分为轻度NAFLD组(40例)、中度NAFLD组(40例)和重度NAFLD组(30例),另外选取同期体检正常者作为对照组(60例)。比较各组身高、体质量、臀围、腰围、甘油三脂、总胆固醇、血糖、肝功能、胰岛素水平、血浆内脏脂肪素水平及胰岛素抵抗(HOMA-IR)情况。结果各组体质量、体质量指数、腰臀比、内脏脂肪素及HOMA-IR比较,差异有统计学意义(P<0.05);轻度NAFLD组、中度NAFLD组、重度NAFLD组内脏脂肪素依次升高,差异有统计学意义(P<0.05);轻度NAFLD组、中度NAFLD组、重度NAFLD组HOMA-IR比较,差异有统计学意义(P<0.05);相关性分析显示,血浆内脏脂肪素水平与HOMA-IR呈正相关;轻度NAFLD组、中度NAFLD组、重度NAFLD组中,内脏脂肪素与HOMA-IR的相关性依次增强(r=0.253、0.508、0.650)。结论非酒精性脂肪性肝病患者血浆内脏脂肪素水平及HOMA-IR高于健康人群,其与胰岛素抵抗存在一定的关系。

Objective To investigate the relationship between plasma and insulin resistance in patients with non-alcoholic fatty liver disease(NAFLD).Methods A total of 110 patients with non-alcoholic fatty liver disease in Liuzhou People’s Hospital from July 2013 to December 2014 were selected.According to the severity,they were divided into mild NAFLD group(40 cases),moderate NAFLD group(40 cases)and severe NAFLD group(30 cases).In addition,people with normal physical examination during the same period were selected as the control group(60 cases).Compare the height,body weight,hip circumference,waist circumference,triglycerides,total cholesterol,blood sugar,liver function,insulin level,plasma visceral fat level and insulin resistance(HOMA-IR)in each group.Results There were statistically significant differences in body mass,body mass index,waist-to-hip ratio,visceral fat and HOMA-IR in each group(P<0.05);Visceral fats in the mild NAFLD group,moderate NAFLD group,and severe NAFLD group increased sequentially,the difference was statistically significant(P<0.05);Comparison of HOMA-IR between mild NAFLD group,moderate NAFLD group,and severe NAFLD group,the difference was statistically significant(P<0.05);Correlation analysis showed that plasma visceral levels were positively correlated with HOMA-IR;in the mild NAFLD group,moderate NAFLD group,and severe NAFLD group,the correlation between visceral fat and HOMA-IR increased in turn(r=0.253,0.508,0.650).Conclusion The levels of plasma visceral fat and HOMA-IR in patients with non-alcoholic fatty liver disease are higher than those in healthy people,and there is a certain relationship between them and insulin resistance.