益气活血化痰通络汤治疗缺血性中风病的效果

The effect of Yiqi Huoxue Huatan Tongluo Decoction in the treatment of ischemic stroke

目的探讨益气活血化痰通络汤治疗缺血性中风病(中经络)的效果。方法选择2018年4月—2020年4月安徽省亳州市中医院脑病科接诊的缺血性中风病(中经络)患者102例作为研究对象,按照随机数字表法分为对照组和观察组,各51例。对照组给予常规治疗,观察组在对照组基础上联合益气活血化痰通络汤治疗,均持续治疗4周。比较两组临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、巴氏量表(Barthel指数)评分、中医证候积分、血清高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、同型半胱氨酸(Hcy)水平及不良反应。结果观察组临床总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组NIHSS评分低于治疗前,Barthel指数评分高于治疗前,且观察组NIHSS评分低于对照组,Barthel指数评分高于对照组,差异有统计学意义(P<0.05)。治疗后,两组中医证候积分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清hs-CPR、IL-6、TNF-α和Hcy水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论益气活血化痰通络汤治疗缺血性中风病(中经络)患者的效果显著,值得应用推广。

Objective To study the effect of Yiqi Huoxue Huatan Tongluo Decoction in the treatment of ischemic stroke(meridians and collaterals).Methods One hundred and two patients with ischemic stroke(meridians and collaterals)admitted to Department of Encephalopathy of Bozhou Hospital of Traditional Chinese Medicine in Anhui Province from April 2018 to April 2020 were selected as research objects.They were divided into control group and observation group according to the random number table method,with 51 cases in each group.Control group was given conventional treatment,and observation group was treated with Yiqi Huoxue Huatan Tongluo Decoction on the basis of control group,they were treated for four weeks.Clinical efficacy,NIHSS score,Barthel index score,Chinese medicine syndrome score,serum high sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),homocysteine(Hcy)levels and adverse reactions were compared between two groups.Results Total effective rate of observation group was higher than that of control group(P<0.05).After treatment,NIHSS scores of two groups were lower than those before treatment,Barthel index scores of two groups were higher than those before treatment,and NIHSS score of observation group was lower than that of control group,Barthel index score of observation group was higher than that of control group,the differences were statistically significant(P<0.05).After treatment,Chinese medicine syndrome scores of two groups were lower than those before treatment,and observation group was lower than that control group,the differences were statistically significant(P<0.05).After treatment,the serum hs-CPR,IL-6,TNF-αand Hcy levels of two groups were lower than those before treatment,and observation group was lower than that control group,the differences were statistically significant(P<0.05).Conclusion Yiqi Huoxue Huatan Tongluo Decoction is a significant effect in the treatment of ischemic stroke(meridians and collaterals),which is worthy of application and promotion.