白细胞介素1相关受体SIGIRR在免疫相关疾病中的作用

The role of IL-1 related receptor SIGIRR in immune related diseases

白细胞介素1受体超家族成员SIGIRR,又称为单个免疫球蛋白(Ig)相关受体,被认为在机体炎症发生及抗炎调节中起关键作用。有研究认为,SIGIRR的表达异常会导致肠道炎症、肾盂肾炎、系统性红斑狼疮等疾病的发生,但在其基因过表达情况下又会促进肿瘤生长并潜在引发抗肿瘤免疫损伤。因此,SIGIRR在疾病发生、发展中的作用被认为是一把双刃剑。目前,SIGIRR发挥生物学作用的详细分子机制尚不完全清楚,本文就目前已经发现并证实的SIGIRR在免疫相关疾病中的发生发展和免疫调节中的作用,以及相关的细胞信号通路进行综述。

SIGIRR,a member of the interleukin 1 receptor superfamily,is also known as a single immunoglobulin(Ig)-related receptor,which is believed to play a key role in the development of inflammation and the regulation of anti-inflammatory effects.Some studies believe that the abnormal down-regulation of SIGIRR can lead to intestinal inflammation,pyelonephritis,systemic lupus erythematosus and other diseases,but it can promote tumor growth and potentially cause anti-tumor immune damage when its genes are overexpressed.Therefore,the role of SIGIRR in disease occurrence and development is considered a double-edged sword.At present,the detailed molecular mechanism of SIGIRR's biological role is not fully understood.This article reviews the functions of SIGIRR in the occurrence and development of immune-related diseases and immune regulation,as well as related cell signaling pathways,which have been discovered and confirmed.