肺肠同治法治疗肺脾气虚型儿童哮喘慢性持续期疗效观察

Observation on the curative effect of lung-bowel therapy on childhood asthma of type of lung-spleen Qi deficiency in the chronic persistent phase

目的观察肺肠同治法治疗肺脾气虚型儿童哮喘慢性持续期的效果。方法采用随机数余数法,将2018年11月—2019年6月珠海市人民医院诊治的108例肺脾气虚型慢性持续期哮喘患儿分为对照组、益生菌组、中药组,每组36例。对照组予规律规范吸入布地奈德粉吸入剂治疗,疗程持续试验全过程;益生菌组在对照组治疗基础上加服双歧杆菌乳杆菌三联活菌片,连用2个月;中药组在对照组治疗基础上加服补肺涩肠汤,连用2个月。比较3组患儿干预结束治疗时、随访3个月时中医症状积分、中医症状控制率及C-ACT评分、哮喘控制率。结果干预治疗结束时、随访3个月时,中药组中医症状积分均明显低于对照组和益生菌组(P均<0.05),中医症状总控制率均明显高于对照组和益生菌组(P均<0.05),对照组和益生菌组比较差异均无统计学意义(P均>0.05);干预治疗结束时、随访3个月时,中药组、益生菌组的C-ACT评分及哮喘控制率均明显高于对照组(P均<0.05),中药组有高于益生菌组的趋势,但差异无统计学意义(P均>0.05)。结论补肺涩肠汤所代表的中医肺肠同治法和肠道益生菌代表的西医肺肠同治法治疗肺脾气虚型儿童哮喘慢性持续期疗效显著,补肺涩肠汤能够显著改善患儿肺脾气虚的体质,并在哮喘控制方面有更高的评分和控制率。

Objective It is to observe the effect of lung-bowel therapy in the treatment of childhood asthma of type of lung-spleen Qi deficiency in the chronic persistent phase.Methods A total of 108 children with asthma of type of lung-spleen Qi deficiency in the chronic persistent phase diagnosed and treated in Zhuhai People’s Hospital from November 2018 to June 2019 were divided into a control group,a probiotic group,and a traditional Chinese medicine(TCM)group by the random number remainder method,with 36 cases in each group.The control group was treated with regular and standardized inhalation of budesonide powder inhalation,and the course of treatment continued throughout the study;the probiotic group was treated with lactobacillus bifidobacterium triple viable tablets for 2 months based on the control group;the TCM group was treated with Bufei Sechang Decoction based for 2 months on the control group.The scores of symptoms of TCM,TCM symptom control rate,C-ACT score,and asthma control rate of the three groups were compared at the end of the intervention treatment and 3 months of follow-up.Results At the end of the intervention treatment and 3 months of follow-up,the TCM symptom scores of the TCM group were significantly lower than those of the control group and the probiotic group(all P<0.05),and the total control rate of TCM symptoms was significantly higher than that of the control group and the probiotic group(all P<0.05),there was no significant difference between the control group and the probiotic group(all P>0.05);at the end of the intervention treatment and 3 months of follow-up,the C-ACT scores and asthma control rate of the Chinese medicine group and the probiotic group were significantly higher than those of the control group(all P<0.05),and the TCM group had a tendency to be higher than that of the probiotic group,but the difference was not statistically significant(all P>0.05).Conclusion The lung-bowel therapy,which was represented by Bufei Sechang Decotion in TCM and represented by probiotics in western medicine is significantly effective in the treatment of childhood asthma of type of lung-spleen Qi deficiency in the chronic persistent phase.Bufei Sechang Decoction can significantly improve the constitution of children with lung-spleen Qi deficiency,and have a higher score and control rate in asthma control.