社区获得性肺炎患儿血清维生素D水平研究

Study on serum vitamin D levels in children with community-acquired pneumonia

目的探讨社区获得性肺炎(CAP)患儿血清维生素D(VD)水平与病情严重程度及年龄的关系,以期为儿童CAP的病情预测与评估及VD的补充提供依据。方法选取2018年11月~2019年11月于承德市中心医院住院治疗的145例CAP患儿作为研究对象,根据病情的严重程度将其分为轻症肺炎组(100例)和重症肺炎组(45例),根据年龄将其分为幼儿组(31例)和学龄前组(114例),分别对各组血清25-(OH)D水平进行比较。结果145例CAP患儿血清25-(OH)D平均水平为(23.4±9.0)ng/mL,其中25-(OH)D水平正常89例(61.38%),不足26例(17.93%),缺乏30例(20.69%),严重缺乏0例。轻症肺炎组血清25-(OH)D水平高于重症肺炎组,重症肺炎组血清25-(OH)D不足(含缺乏)检出率高于轻症肺炎组,差异有统计学意义(P<0.05)。幼儿组血清25-(OH)D水平高于学龄前组,差异有统计学意义(P<0.05)。其中轻症肺炎幼儿组血清25-(OH)D水平高于学龄前组,差异有统计学意义(P<0.05),重症肺炎幼儿组血清25-(OH)D水平与学龄前组比较,差异无统计学意义(P>0.05)。结论重症CAP患儿较轻症CAP患儿血清VD水平低,VD水平可能与年龄有关。

Objective To investigate the relationship between serum vitamin D(VD)levels and severity and age of children with community-acquired pneumonia(CAP),so as to provide evidence for the prediction and assessment of the condition of CAP and the supplement of VD.Methods A total of 145 CAP children hospitalized in Chengde Central Hospital from November 2018 to November 2019 were selected as the research objects.According to the severity of the disease,they were divided into mild pneumonia group(100 cases)and severe pneumonia group(45 cases).According to the age,they were divided into infant group(31 cases)and preschool group(114 cases).Serum 25-(OH)D levels were compared in each group.Results The average serum 25-(OH)D level of 145 CAP patients was(23.4±9.0)ng/mL,among which the 25-(OH)D level was normal in 89 cases(61.38%),less in 26 cases(17.93%),deficient in 30 cases(20.69%),and severe deficient in 0 cases.The level of 25-(OH)D in the mild pneumonia group was higher than that in the severe pneumonia group,and the detection rate of 25-(OH)D deficiency(including deficiency)in the severe pneumonia group was higher than that in the mild pneumonia group,and the differences were statistically significant(P<0.05).The serum level of 25-(OH)D in the infant group was higher than that in the preschool group,and the difference was statistically significant(P<0.05).The level of 25-(OH)D in the infant group with mild pneumonia was higher than that of the preschool group,and the difference was statistically significant(P<0.05).There was no significant difference in serum 25-(OH)D level between the children with severe pneumonia group and the preschool group(P>0.05).Conclusion The serum VD level of children with severe CAP is lower than that of children with mild CAP,which may be related to age.