葛根素微胶囊的制备及其性质研究

Preparation and Properties of Puerarin Microcapsules

以阿拉伯胶和β-环状糊精为壁材,采用喷雾干燥法制备葛根素微胶囊。通过单因素实验和正交试验考察复合乳化剂配比、乳化剂添加量、β-环状糊精和阿拉伯胶质量比、壁芯比和固形物含量对乳化液稳定性的影响,同时考察进风温度、进料量、均质时间对葛根素微胶囊包埋率的影响。结果表明,葛根素微胶囊的最佳工艺条件为:复合乳化剂(单甘酯:蔗糖酯)质量比4:6(g/g),乳化剂添加量为1.6%,壁材(β-环糊精:阿拉伯胶)比为5:3(g/g),壁芯比为1:0.15(g/g),固形物含量15%,进口温度160℃,进料量为4 mL/min,均质时间为6 min,此条件下的葛根素微胶囊包埋率为91.16%,微胶囊产品为乳白色粉末、细腻均匀无异味,扫描电子显微镜结果显示微胶囊呈较光滑球形,粒径约为15~25μm,水分含量为2.83%,堆积密度为0.55 g/cm3,休止角为33.60°。因此,最佳制备条件下的微胶囊产品品质较优,有利于贮藏且具有较好的流动性和溶解性,能够为葛根素微胶囊的开发利用提供参考依据。

The aim of this study is to optimize the experimental conditions for the preparation of Puerarin microcapsules via the spray-drying using gum arabic andβ-cyclodextrinas wall materials.The effects of compound emulsifier ratio,emulsifier concentration,β-cyclodextrin/gum arabic ratio,wall/core ratio and solid concentration on emulsion stability were investigated,as well as the effect of inlet air temperature,feed flow rate and homogenization time on microencapsulation efficiency.The results showed that the maximum encapsulation efficiency of 91.16%was achieved under following condition:composite emulsifier(monoglyceride:sucrose ester=4:6,g/g),emulsifier concentration 1.6%,β-cyclodextrin/gum arabic ratio 5:3(g/g),wall/core ratio 1:0.15(g/g),solid concentration 15%,inlet temperature 160℃,feed flow rate 4 mL/min,homogenization time 6 min.SEM examination showed that the obtained microcapsules were spherical in shape with smooth and continuous surfaces,witha particle size of 15~25μm.It had a moisture of 2.83%,bulk density of 0.55 g/cm3and angle of repose of 33.60°.Therefore,high-quality microcapsules were obtained under the optimized condition,which had good fluidity and solubility,and can provide reference for the development and utilization of puerarin microcapsules.