乳酸菌改善糖尿病代谢作用机制研究进展

Research Progress on the Mechanism of Lactic Acid Bacteria in Improving Diabetes Metabolism

乳酸菌对糖尿病人有良好的治疗功效,其机制的探究也越发深入。乳酸菌可抑制肠道中α-葡萄糖苷酶使血糖降低,经由调节胰岛素信号传导、糖代谢、脂质代谢等相关代谢途径来降低血糖水平,通过促进胰岛素的表达或降低磷酸化水平改善胰岛素抵抗,影响机体内的葡萄糖转运因子进而从糖的重吸收等方面影响葡萄糖的代谢,下调脂肪合成酶的表达以抑制脂肪生成,同时改善肠道菌群的丰度并影响肠道菌群的完整性对炎症反应和代谢紊乱进行修复。本文对目前研究乳酸菌改善糖尿病的具体作用机制进行研究论述,为未来乳酸菌预防和治疗糖尿病提供参考。

Lactic acid bacteria have a good therapeutic effect on diabetic patients,and the exploration of its mechanism has been intensified.Lactic acid bacteria can inhibitα-glucosidase in the intestine to reduce blood sugar,and reduce blood sugar levels by regulating insulin signal transduction,sugar metabolism,lipid metabolism and other related metabolic pathways.Promote insulin expression or reduce phosphorylation level to improve insulin resistance and affect the body.The glucose transport factors in turn affects glucose metabolism from the aspects of sugar reabsorption,down-regulates the expression of liposynthetase,inhibits adipogenesis,improves the abundance of intestinal flora and affects the integrity of intestinal flora,and affects inflammation and metabolic disorders to repair it.This article reviews the current research on the specific mechanism of lactic acid bacteria in improving diabetes,and provides references for the future prevention and treatment of diabetes by lactic acid bacteria.