曲唑酮致唾液分泌增加

Increased salivary secretion caused by trazodone

1例52岁男性患者因抑郁障碍给予艾司西酞普兰5 mg/d(逐渐加量至15 mg/d),曲唑酮100 mg/d,劳拉西泮1 mg/d。服药3 d后患者出现唾液分泌增加。服药13 d后因曲唑酮缺药仅服用艾司西酞普兰和劳拉西泮。停用曲唑酮3 d后,唾液分泌增加症状消失。后因睡眠不佳重新加用曲唑酮100 mg/d,2 d后患者再次出现唾液分泌增加。医师考虑上述症状与曲唑酮有关,嘱其停用该药,仅继续服用艾司西酞普兰和劳拉西泮。3 d后,患者唾液分泌增加再次消失。2周后复诊,患者抑郁症状缓解,未再出现唾液分泌增加。

A 52-year-old male patient was given escitalopram 5 mg/d(gradually increased to 15 mg/d),trazodone 100 mg/d,and lorazepam 1 mg/d for depression.Increased salivary secretion occurred 3 days after taking the medicine.After 13 days of taking the medicine,she only took escitalopram and lorazepam due to lack of trazodone.After stopping trazodone for 3 days,the symptoms of increased salivary secretion disappeared.Trazodone 100 mg/d was added again later due to poor sleep and increased salivary secretion relapsed after 2 days of trazodone administration.Considering that the above symptoms were related to trazodone,the doctor ordered him to stop the drug and take escitalopram and lorazepam only.Three days later,the patient′s increased salivary secretion disappeared again.The patient′s depressive symptoms were relieved and increased salivary secretion did not recur at a 2-week follow-up.