摘要
在机体免疫系统中炎症反应占有重要地位,中性粒细胞作为固有免疫细胞中的重要组成部分,在炎症相关疾病的发生发展过程中也起到了关键作用。中性粒细胞胞外诱捕网(neutrophil extracellular traps, NETs)具有杀灭外来微生物和引起炎症反应等作用。本文以2016年以来NETs的研究论文为依据,对NETs在人体不同系统中炎症相关疾病的作用进行了综述,并总结了可靶向NETs改善炎症相关疾病的药物,为从靶向NETs的角度治疗炎症相关疾病提供了新的研究思路。
The inflammatory response is an essential role of innate immune cells such as neutrophils, which plays an important role in the occurrence and development of inflammatory diseases. Neutrophil extracellular traps(NETs) are responsible for killing microorganisms and inducing the inflammatory response. We review the function of NETs in inflammatory diseases based on research publications since 2016. In addition, the ability of drugs that target NETs to ameliorate inflammation-related diseases is summarized. This review suggests a new strategy of targeting NETs for the treatment of inflammation-related diseases.
作者
丁衍
瞿娇
孙洋
DING Yan;QU Jiao;SUN Yang(State Key Laboratory of Pharmaceutical Biotechnology,Department of Biotechnology and Pharmaceutical Sciences,School of Life Sciences,Nanjing University,Nanjing 210023,China)
出处
《药学学报》
CAS
CSCD
北大核心
2021年第3期669-678,共10页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81872877)。
关键词
中性粒细胞胞外诱捕网
炎症性疾病
炎症
靶向治疗
neutrophil extracellular trap
inflammatory disease
inflammation
targeting therapy
