中西医结合治疗肝郁脾虚型帕金森病抑郁25例临床观察

Clinical Observation of 25 Cases of Parkinson’s Disease Depression with Liver Depression and Spleen Deficiency Treated by Combine Traditional Chinese and Western Medicine

目的:观察中西医结合治疗肝郁脾虚型帕金森病抑郁患者的临床疗效。方法:选取帕金森病合并抑郁且中医辨证为肝郁脾虚型的患者50例,随机分为对照组25例,观察组25例,两组病例均在基础治疗上予以米氮平口服,观察组加用逍遥散合柴胡疏肝散,每日1剂,早晚分服。两组均治疗4周。治疗前后分别使用汉密尔顿抑郁评定量表(HAMD)、帕金森病评定量表第一部分(UPDRS partⅠ),中医症候评分评估患者抑郁症状。结果:治疗后两组汉密尔顿抑郁量表、帕金森病评定量表、中医症候评分均较治疗前降低,且观察组较对照组下降更明显。结论:中西医结合治疗帕金森病合并抑郁患者疗效较好。

Objective To observe the clinical efficacy of combine traditional Chinese and western medicine in the treatment of depression of Parkinson’s disease with liver depression and spleen deficiency.Methods 50 patients with Parkinson’s disease and depression with liver stagnation and spleen deficiency were randomly divided into control group(25 cases)and observation group(25 cases).On the basis of basic treatment,the two groups were given mirtazapine orally,while the observation group was given Xiaoyao san and Chaihu Shugan san,one dose a day,in the morning and evening.Both groups were treated for 4 weeks.Before and after treatment,Hamilton Depression Rating Scale(HAMD),Parkinson’s disease rating scale part I(UPDRS part I)and TCM symptom score were used to evaluate the depressive symptoms.Results After 4 weeks of treatment,Hamilton Depression Scale,Parkinson’s disease rating scale and TCM symptom score of the two groups were lower than before treatment,and the observation group was significantly lower than the control group.Conclusion The therapeutic effect of combine traditional Chinese and western medicine on Parkinson’s disease complicated with depression is obvious.