血管生成素2在脓毒症及肺损伤儿童中的应用研究

Application of angiopoietin 2 in children with sepsis and lung injury

目的研究探讨血管生成素2在脓毒症及肺损伤儿童血清中的变化情况及临床意义。方法选择我院2019年7~12月的脓毒症患儿90例,按病情严重程度分为脓毒症组63例和脓毒性休克组27例,同期选取健康体检儿童30例为对照组。90例脓毒症患儿中有肺损伤25例。观察各组研究对象血管生成素2水平情况以及脓毒症及肺损伤患儿血管生成素2水平。结果(1)脓毒症、脓毒性休克患儿血管生成素2水平显著高于健康儿童,差异有统计学意义(P<0.05)。脓毒症组血管生成素2水平显著低于脓毒性休克组,差异有统计学意义(P<0.05)。(2)脓毒症并发肺损伤时,患儿机体血管生成素2水平显著高于无肺损伤患儿,差异有统计学意义(P<0.05)。结论血浆Ang2水平可用来辅助判断脓毒症患儿病情严重程度,动态检测血浆Ang2水平可用于评估脓毒症患儿预后。不仅可有效检查脓毒症患儿病情严重程度,还可早期预测脓毒症及肺损伤的发生,从而为临床后续治疗提供支持。

Objective To study the changes and clinical significance of angiopoietin 2 in the serum of children with sepsis and lung injury.Methods A total of 90 children with sepsis treated in our hospital from July to December of 2019 were included in the study,who were divided into two groups based on the severity of disease:63 in the sepsis group and 27 in the septic shock group.Another 30 children undergoing physical examination during the same period were chosen as the control group.Among the 90 children with sepsis,25 had lung injury.The level of angiopoietin 2 was observed in the three groups and in the children with sepsis and lung injury.Results(1)The level of angiopoietin 2 in the sepsis group and septic shock group was significantly higher than that in control group(P<0.05).The level of angiopoietin 2 in sepsis group was significantly lower than that in septic shock group(P<0.05).(2)The level of angiopoietin 2 in the children with sepsis and lung injury was significantly higher than that in the septic children without lung injury(P<0.05).Conclusion Angiopoietin 2 has become an important biomarker in clinical determination of sepsis.It can not only indicate the disease severity but also predict the occurrence of sepsis and lung injury at an early stage,which provides support for the following clinical treatment.