血清氧化三甲胺与冠心病的相关性研究

Study on correlation of serum trimethylamine oxide and coronary heart disease

目的研究血清氧化三甲胺(TMAO)与冠心病(CHD)的发生是否具有相关性。方法选取2019年7月—2020年6月在蚌埠医学院附属连云港市第二人民医院(以下简称“我院”)心血管内科住院CHD患者98例为CHD组,同期我院门诊体检健康志愿者104名为对照组,采用酶联反应吸附试验检测两组血清TMAO。比较两组一般资料及血清TMAO水平。采用多因素logistic回归分析CHD的相关因素,Spearman相关系数分析血清TMAO水平与CHD严重程度的相关性。结果CHD组的男性占比、体重指数(BMI)、吸烟占比、血清TMAO、血糖、合并高脂血症占比、合并高血压病占比均明显高于对照组,差异均有统计学意义(均P<0.05)。多因素logistic回归分析显示高TMAO水平、高BMI、高血糖水平、合并高脂血症、吸烟史、合并高血压病、高尿酸水平均是CHD的危险因素(OR>1,P<0.05)。Spearman相关系数显示TMAO与CHD严重程度呈正相关(rs=0.443,P<0.05)。结论CHD患者血清TMAO水平较高,其与CHD的发生具有一定相关性。

Objective To study the correl ation of serum trimethylamine oxide(TMAO)and the occurrence of coronary heart disease(CHD).Methods A total of 98 patients with CHD hospitalized in the Department of Cardiovascular Medicine,the Second People’s Hospital of Lianyungang Affiliated to Bengbu Medical College(hereinafter referred to“our hospital”)from July 2019 to June 2020 were selected as the CHD group and 104 healthy volunteers at the same period in our hospital were selected as the control group.Serum TMAO in the two groups were detected by enzymatic linked reaction adsorption assay.The general data and serum TMAO level of the two groups were compared.Multivariate logistic regression was used to analyze the risk factors of CHD,and Spearman correlation coefficient was used to analyze the correlation between serum TMAO level and the severity of CHD.Results The number of male,body mass index(BMI),smoking proportion,serum TMAO,blood glucose,hyperlipidemia and hypertension proportion in the CHD group were significantly higher than those in the control group,with statistical significance(all P<0.05).Multivariate logistic regression analysis showed that high TMAO level,high BMI,high blood glucose level,complicated with hyperlipidemia,smoking history,complicated with hypertension and high uric acid level were all risk factors for CHD(OR>1,P<0.05).Spearman correlation coefficient showed that TMAO was positively correlated with CHD severity(rs=0.443,P<0.05).Conclusion The serum TMAO level is higher in patients with CHD,which has a certain correlation with the occurrence of CHD.