PON1 Q192R基因多态性与氯吡格雷治疗的脑梗死患者复发相关性研究

Relationship between PON1 Q192R gene polymorphism and recurrence of cerebral infarction patients treated with Clopidogrel

目的研究PON1基因多态性及其与氯吡格雷治疗脑梗死患者复发的相关性。方法选取2012年10月—2019年3月河北中石油中心医院接受氯吡格雷治疗的脑梗死患者共205例,根据纳入排除标准,最终纳入169例患者为研究对象。应用原位杂交技术检测PON1 Q192R和CYP2C19基因。将未发生基因突变的患者纳入QQ组(61例),发生基因突变的患者纳入QR+RR组(108例)。计算相对危险度,分析PON1 Q192R基因与脑梗死患者复发的相关性。结果两组患者90 d和1年内脑梗死复发率比较,差异无统计学意义(P>0.05);同一CYP2C19基因型背景下,两组患者90 d和1年内脑梗死复发率比较,差异无统计学意义(P>0.05)。90 d和1年内,QR+RR组患者脑梗死复发的相对危险度分别为1.2、1.3,PON1 Q192R基因与脑梗死复发率呈弱相关。结论PON1 Q192R基因多态性可能是脑梗死患者90 d和1年内复发的遗传易感因素。

Objective To study the relationship between PON1 gene polymorphism and recurrence of cerebral infarction patients treated with Clopidogrel.Methods A total of 205 patients with cerebral infarction who received Clopidogrel treatment in Hebei Petrochina Central Hospital from October 2012 to March 2019 were selected,according to the inclusion and exclusion criteria,169 patients were finally included as the study subjects.Situ hybridization was used to detect PON1 Q192R and CYP2C19 genes.Patients without gene mutation were included in QQ group(61 cases),and patients with gene mutation were included in QR+RR group(108 cases).The relative risk was calculated and the correlation between PON1 Q192R gene and recurrence of cerebral infarction patients was analyzed.Results There were no significant differences in the recurrence rate of cerebral infarction at 90 d and 1 year between two groups(P>0.05).Under the same CYP2C19 genotype background,there were no significant differences in the recurrence rate of cerebral infarction in 90 d and 1 year between two groups(P>0.05).The relative risk of recurrence of cerebral infarction in QR+RR group was 1.2,1.3 at 90 d and 1 year,respectively.PON1 Q192R gene was weakly correlated with the reate of recurrence of cerebral infarction.Conclusion PON1 Q192R gene polymorphism may be a genetic susceptibility factor for recurrence of cerebral infarction patients at 90 d and 1 year.