寒喘祖帕颗粒配合乙酰半胱氨酸对COPD患者肺功能、TGF-β及MMP-9水平的影响

Effects of Hanchuan Zupa Granules and Acetylcysteine on Pulmonary Function,the Levels of TGF-β and MMP-9 in COPD Patients

目的:探讨寒喘祖帕颗粒配合乙酰半胱氨酸对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者肺功能、转化生长因子β(transforming growth factor-β,TGF-β)及基质金属蛋白酶9(matrix metalloprotein-9,MMP-9)水平的影响。方法:选取206例COPD患者,将受试者按入院顺序分为两组,每组103例。对照组接受乙酰半胱氨酸治疗,观察组在此基础上给予寒喘祖帕颗粒治疗,比较两组临床疗效、治疗前后各组肺功能指标及血清TGF-β、MMP-9水平变化情况和不良反应发生情况。结果:总有效率观察组为94.17%(97/103),对照组为77.67%(80/103),两组比较差异有统计学差异(P<0.05);治疗后两组一秒用力呼气容积(forced expiratory volume in one second,FEV1)、用力肺活量(forced vital capacity,FVC)呼气峰值流速(peak expiratory flow,PEF)、最大呼气中期流量(maximal mid-expiratory flow,MMEF)及FEV1/FVC较治疗前均明显提高(P<0.05),且观察组显著高于对照组(P<0.05);治疗后两组TGF-β及MMP-9水平较治疗前均明显降低,且观察组低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:寒喘祖帕颗粒配合乙酰半胱氨酸可有效改善COPD患者肺功能、降低TGF-β及MMP-9水平,且安全性高。

Objective:To explore the effects of Hanchuan Zupa granules and acetylcysteine on pulmonary function,the levels of TGF-βand MMP-9 in COPD patients.Methods:All 206 patients hospitalized were chosen and allocated to two groups,103 patients of the control group were treated by acetylcysteine,and 103 patients of the observation group took Hanchuan Zupa granules orally,to compare clinical effects,the indexes of pulmonary functions in different groups before and after treating,the levels of TGF-βand MMP-9 and the incidence of adverse reaction between both groups.Results:Total effective rate of the observation group was 94.17%(97/103),higher than 77.67%(80/103)of the control group,and the difference showed statistical meaning between both groups(P<0.05);after the treatment,FEV1,FVC,PEF,MMEF and FEV1/FVC of the two groups increased apparently than before treating(P<0.05),and the observation group was notably higher than the control group,and the difference showed statistical meaning(P<0.05);after the treatment,the levels of TGF-βand MMP-9 in both groups were lower compared with these before treating,and the observation group was lower than the control group(P<0.05);the difference had no statistical meaning in the incidence of adverse reaction between both groups(P>0.05).Conclusion:Hanchuan Zupa granules and acetylcysteine could improve pulmonary function of the patients effectively,reduce the levels of TGF-βand MMP-9 with high safety.