生物制剂治疗类天疱疮的研究进展

Upadate of biologicals for treating pemphigoid

类天疱疮是一组自身免疫性表皮下大疱病,包括大疱性类天疱疮、黏膜类天疱疮、妊娠类天疱疮等。外用或系统应用糖皮质激素和免疫抑制剂是类天疱疮传统的治疗方法,长期使用易发生严重不良反应,近年来一些学者使用生物制剂治疗类天疱疮取得一定疗效,现将生物制剂治疗类天疱疮的研究进展进行综述。

Pemphigoid is a term for heterogeneous blistering disorders including bullous pemphigoid(BP),mucous membrane pemphigoid(MMP),Pemphigoid gestationis(PG),etc.Conventional therapy includes systemic corticosteroids(CS)and immunosuppressive agents(ISA),which is often accompanied by significant adverse reactions after long term treatment.Many scholars have tried to use biological agents to treat pemphigoid and achieved certain efficacy.The update of biological agents in the treatment of pemphigoid is reviewed in this paper.