早期宫颈癌淋巴脉管间隙浸润与其预后生存的关系研究

Relationship between lymphatic vascular space invasion in early cervical cancer and its prognosis

目的:探讨早期宫颈癌淋巴脉管间隙浸润与其预后生存的关系。方法:回顾性分析2013年5月至2016年5月本院收治的经实验室检查确诊为早期宫颈的84例患者的临床资料。整理患者术后病理检查结果,分析影响早期宫颈癌淋巴脉管间隙浸润对患者预后的影响。结果:经非条件单因素Logistic回归模型分析得出:组织学分型、分化程度、淋巴结转移、宫颈间质浸润深度为影响早期宫颈癌阳性淋巴脉管间隙浸润患者预后生存的单因素(P<0.05);经非条件多因素Logistic回归模型进一步分析,得出:低度分化、有淋巴结转移、宫颈间质浸润深度≧1/2为影响早期宫颈癌阳性淋巴脉管间隙浸润患者预后生存的危险因素(P<0.05);阳性、阴性淋巴脉管间隙浸润组患者4年内总生存率分别为77.50%、93.18%,4年无疾病进展生存率分别为67.50%、86.36%,相比存在统计学差异(P<0.05)。结论:淋巴脉管间隙浸润是影响早期宫颈癌患者预后生存的重要因素之一;低度分化、有淋巴结转移、宫颈间质浸润深度≧1/2为影响早期宫颈癌阳性淋巴脉管间隙浸润患者预后生存的危险因素。

Objective:To explore the relationship between lymphatic vascular space invasion in early cervical cancer and its prognosis.Methods:The clinical data of 84 patients with early cervical cancer diagnosed by laboratory examinations who were admitted to our hospital from May 2013 to May 2016 were retrospectively analyzed.The results of the postoperative pathological examination of the patient were sorted out,and the influence of the lymphatic vascular space infiltration in early cervical cancer on the prognosis of the patient was analyzed.Results:Analysis of unconditional single factor Logistic regression model showed that histological type,degree of differentiation,lymph node metastasis,and depth of cervical interstitial invasion are the single factors that affect the prognostic survival of patients with positive lymphovascular space invasion in early cervical cancer(P<0.05).Further analysis of the unconditional multivariate logistic regression model showed that low-grade differentiation,presence of lymph node metastasis,and the depth of cervical interstitial invasion≥1/2 are risk factors affecting the prognostic survival of patients with positive lymphovascular space invasion in early cervical cancer(P<0.05).The four-year overall survival rates of patients in the positive and negative lymphatic vascular space infiltration groups were 77.50%and 93.18%,respectively,and the progress-free survival rates within 4 years were 67.50%and 86.36%,respectively,and there was significantly statistical differences(P<0.05).Conclusions:Lymphatic vascular space invasion is one of the important factors affecting the prognostic survival of patients with early cervical cancer.Low-grade differentiation,lymph node metastasis,and depth of cervical interstitial invasion≥1/2 are risk factors that affect the prognostic survival of patients with positive lymphatic vascular space invasion in early cervical cancer.