果胶铋联合三联疗法对消化性溃疡患者血清炎症介质及生命质量的影响

Effect of Pectin Bismuth Combined with Triple Therapy on Serum Inflammatory Factors and Quality of Life in Patients with Peptic Ulcer

目的探讨果胶铋联合三联疗法对消化性溃疡患者血清炎症介质及生命质量的影响。方法选取2019年8月至2020年2月于大石桥市第三人民医院治疗的90例消化性溃疡患者作为研究对象,按随机数字表法分为对照组与观察组,每组45例。对照组患者予以呋喃唑酮片+奥美拉唑肠溶胶囊+阿莫西林治疗,观察组患者在对照组治疗基础上采用胶体果胶铋胶囊治疗。比较两组患者治疗后幽门螺杆菌(Hp)根除率,以及治疗前后血清一氧化氮(NO)、一氧化氮合酶(NOS)、炎症介质、消化病生命质量指数(GLQI)评分。结果治疗后,观察组Hp根除率为97.78%,明显高于对照组的77.78%,差异有统计学意义(P<0.05)。治疗前,两组患者血清NO、NOS、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平及GLQI评分差异无统计学意义(P>0.05);治疗后,两组患者血清NO、NOS、IL-6、IL-8水平及GLQI评分较治疗前有所改善,且观察组明显优于对照组,差异有统计学意义(P<0.05)。结论果胶铋联合三联疗法可通过降低胃溃疡患者血清IL-6、IL-8水平,提高NO、NOS水平,发挥改善胃黏膜微循环、提高黏膜血容量、减轻炎症反应、抑制胃酸形成、保护胃黏膜、提高患者生命质量的作用。

Objective To explore the effect of pectin bismuth combined with triple therapy on serum inflammatory factors and quality of life in patients with peptic ulcer. Methods A total of 90 patients with Helicobacter pylori infection admitted to Dashiqiao Third People’s Hospital from August 2019 to February 2020 were selected as the research objects and were randomly divided into a control group and an observation group, with 45 cases in each group. Patients in the control group were treated with furazolidone tablets + omeprazole enteric-coated capsules + amoxicillin, and patients in the observation group were treated with colloidal pectin bismuth capsules plus furazolidone tablets + omeprazole enteric-coated capsules + amoxicillin. The eradication rate of Helicobacter pylori(Hp) after treatment, and serum nitric oxide(NO), nitric oxide synthase(NOS), inflammatory mediators, and digestive life quality index(GLQI) scores before and after treatment were compared between the 2 groups. Results After treatment, the Hp eradication rate of the treatment group was 97.78%, which was significantly higher than that of the control group of 77.78%. The difference was statistically significant(P<0.05). Before treatment, there were no significant differences in serum NO and NOS levels, serum IL-6 and IL-8 levels, and GLQI score(P>0.05). After treatment, the levels of serum NO and NOS, the levels of serum IL-6, IL-8 and GLQI scores of the 2 groups of patients improved. And the observation group was significantly better than the control group, the difference was statistically significant(P<0.05). Conclusion Bismuth pectin combined with triple therapy can reduce the levels of serum IL-6 and IL-8 and GLQI score in patients with gastric ulcer, increase the levels of NO and NOS, improve gastric mucosal microcirculation, increase mucosal blood volume, relieve inflammatory reactions, protect gastric mucosa and improve the quality of life of patients.