泼尼松联合七叶皂苷钠治疗面神经炎的疗效及对调节性T细胞/辅助性T细胞17细胞因子、自由基生成的影响

Efficacy of Prednisone Combined with Sodium Aescinate in the Treatment of Facial Neuritis and Their Effect on the Production of Treg/Th17 Cytokines and Free Radicals

目的探讨泼尼松联合七叶皂甙钠治疗面神经炎的疗效及对调节性T细胞(Treg)/辅助性T细胞17(Th17)细胞因子、自由基生成的影响。方法选取2017年9月至2020年4月于瓦房店第三医院接受治疗的面神经炎患者90例作为研究对象,按随机数字表法分为对照组与观察组,各45例。对照组在常规治疗基础上加入泼尼松治疗,观察组患者在常规治疗基础上采用泼尼松、七叶皂苷钠治疗,持续1周后评估疗效。比较两组患者近期疗效、血清Treg/Th17细胞因子[白细胞介素-10(IL-10)、转化生长因子-β(TGF-β)、白细胞介素-17(IL-17)、白细胞介素-22(IL-22)]及自由基生成相关指标[晚期氧化蛋白产物(AOPPs)、一氧化氮(NO)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)]水平,记录治疗期间药物相关不良反应发生情况。结果治疗后,观察组患者治疗有效率高于对照组患者(P<0.05),血清IL-10、TGF-β、CAT、SOD水平高于对照组(P<0.05),IL-17、IL-22、AOPPs、NO水平低于对照组(P<0.05)。治疗期间,两组患者皮疹、头晕头痛、腹泻便秘发生率比较差异无统计学意义(P>0.05)。结论面神经炎患者的治疗方案中加入七叶皂苷钠,有助于提升疗效及减轻机体炎症应激状态,且具有良好的治疗安全性。

Objective To investigate the efficacy of prednisone combined with sodium aescinate in the treatment patients with facial neuritis and their effect on the production of Treg/Th17 cytokines and free radicals. Methods A total of 90 patients with facial neuritis patients admitted to the Third Hospital of Wafangdian City during September 2017 to April 2020 were selected as the research objects and were randomly divided into a control group and an observation group with 45 cases in each group. Patients in control group were treated with prednisone on the basis of routine treatment, while those in observation group were treated with prednisone and sodium aescinate on the basis of routine treatment, and curative effect was evaluated after 1 week. The short-term efficacy, serum levels of Treg/Th17 cytokines [interleukin-10(IL-10), tumor necrosis factor-beta(TGF-β), interleukin-17(IL-17), interleukin-22(IL-22)] and free radical production related indicators [advanced protein oxidation products(AOPPs), nitric oxide(NO), catalase(CAT), superoxide dismutase(SOD)] were compared between 2 groups. The occurrence of adverse drug reactions during treatment were recorded. Results After treatment, total effective rate of the observation group was higher than that of control group(P<0.05). Serum levels of IL-10, TGF-β, CAT and SOD were higher than those in control group, while levels of IL-17, IL-22, AOPPs and NO were lower than those in control group(P<0.05). There were no significant difference in the incidence of skin rash, dizziness, headache, diarrhea and constipation between the 2 groups(P>0.05). Conclusion Sodium aescinate added to the treatment of facial neuritis is helpful to improve the curative effect and alleviate inflammation stress, and has good therapeutic safety.