血清镁离子水平在儿童支气管哮喘急性发作期的临床应用价值

Clinical significance of serum magnesium level in children with acute exacerbation of bronchial asthma

目的探讨血清镁离子水平在儿童支气管哮喘急性发作期的变化及临床意义。方法选取儿童哮喘患者260例,其中哮喘急性发作期患儿118例,哮喘临床缓解期患儿142例,另选取140例健康体检儿童为对照组;比较各组血清镁离子水平的差异;采用Logistic回归分析血清镁离子水平与儿童哮喘急性发作的关系;ROC曲线评估血清镁离子水平对儿童哮喘急性发作的预测价值。结果急性发作期患儿血清镁离子水平显著低于临床缓解组和对照组(P<0.05);随着哮喘急性发作严重程度的增加,血清镁离子水平也逐渐降低,即重度发作组患儿血清镁离子水平显著低于中度发作组和轻度发作组(P<0.05);Logistic回归分析提示血清镁离子水平降低是儿童哮喘急性发作的独立危险因素(OR=0.742,95%CI:0.516~0.875,P=0.012);ROC曲线分析提示血清镁离子水平对儿童哮喘急性发作有较好的预测价值,曲线下面积为0.784(95%CI:0.716~0.852,P<0.01)。结论血清镁离子水平与儿童哮喘急性发作严重程度密切相关,可作为预测儿童哮喘急性发作的一种临床指标。

Objective To investigate the changes of serum magnesium level and its clinical significance in acute exacerbation of bronchial asthma of children.Methods A total of 118 children in acute exacerbation of bronchial asthma,142 children in remission stage of bronchial asthma and 140 healthy children were enrolled into our study.Differences of serum magnesium level among these three groups were compared.The risk factors for exacerbation of bronchial asthma were analyzed by Logistic regression.We also used ROC curve to evaluate the predictive value of serum magnesium level for acute asthma exacerbations.Results Serum magnesium level was higher in children with acute exacerbation of bronchial asthma that that in the remission stage and the control groups(P<0.05).Children in the severe asthma exacerbation group had lower serum magnesium level than that in the mild and moderate asthma exacerbation groups(P<0.05).Logistic analysis showed that serum magnesium level(OR=0.742,95%CI:0.516-0.875,P=0.012)was an independent factor for acute exacerbation of bronchial asthma of children.ROC curve analysis suggests that serum magnesium level had a good predictive value for acute asthma exacerbations of children.The area under the curve was 0.784(95%CI:0.716-0.852,P<0.01).Conclusion Serum magnesium ion level is closely related to the severity of acute asthma attack in children,which can be used as a clinical index to predict the acute asthma attack in children.