天然产物抗乳腺肿瘤纳米给药系统研究进展

Advances in the Research of Natural Products Anti-Breast Tumor Nanometer Drug Delivery System

乳腺肿瘤常发于女性且死亡率高。天然产物在乳腺肿瘤治疗上有独特的优势,但水溶性差、生物利用度低、选择性差、易发生不良反应等缺点限制了其在临床上的发展应用。纳米技术的迅猛发展使其成为药物递送的理想载体,其可克服天然产物的原生缺陷,为更多天然产物发展为良好的抗乳腺肿瘤备选药物提供了可能。大量研究表明,纳米给药系统在天然产物抗乳腺肿瘤临床应用中具有广阔前景。笔者就天然产物抗乳腺肿瘤纳米给药系统研究进展展开综述。

Breast tumors often occur in women and have a high mortality rate.Natural products have unique advantages in the treatment of breast tumors,but the disadvantages such as poor water solubility,low bioavailability,poor selectivity and easy to produce adverse reactions limit their clinical application.The rapid development of nanotechnology makes it an ideal vehicle for drug delivery,which can overcome the original defects of natural products and provide the possibility for the development of more natural products as good anti-breast tumor drug candidates.A large number of studies have shown that nano drug delivery system has a broad prospect in the clinical application of natural products against breast tumors.In this paper,the research progress of nano drug delivery system of natural products against breast tumor is reviewed.