血清脂滴蛋白-5检测对急性ST段抬高型心肌梗死病变预后的评估价值

The prognostic value of serum lipid drop protein-5 in acute ST-segment elevation myocardial infarction

目的研究血清脂滴蛋白-5检测对急性ST段抬高型心肌梗死(STEMI)患者预后的评估价值。方法采用回顾性分析方法,研究对象为2018年6月至2019年6月青海省心脑血管病专科医院收治的64例STEMI患者,所有患者均于入院次日检测血清脂滴蛋白-5水平,并根据脂滴蛋白-5表达水平分为低表达组(<3.12μg/L)和高表达组(>3.12μg/L),各32例。比较2组患者冠状动脉病变程度,比较1年内死亡与存活患者的血清脂滴蛋白-5水平,随访1年内心血管不良事件发生率、病死率。结果低表达组3只血管病变率(33.33%)明显高于高表达组(4.17%),差异有统计学意义(P<0.05)。1年内死亡患者的血清脂滴蛋白-5表达水平[(1.69±0.32)μg/L]明显低于存活患者[(4.07±0.81)μg/L],差异有统计学意义(P<0.05)。低表达组1周、1个月、6个月及1年的病死率(15.63%、18.75%、25.00%、37.50%)明显高于高表达组(0、3.13%、6.25%、12.50%),差异均有统计学意义(P<0.05)。低表达组1周、1个月、6个月及1年的心血管不良事件发生率(21.88%、31.25%、40.63%、56.25%)明显高于高表达组(3.13%、6.25%、9.38%、15.63%),差异均有统计学意义(P<0.05)。结论血清脂滴蛋白-5表达水平与STEMI患者的近远期预后及冠状动脉病变程度显著相关,血清脂滴蛋白-5表达水平越低,预后越差。

Objective To investigate the prognostic value of serum perilipin-5 in patients with ACUTE ST-elevation Myocardial Infarction(STEMI).Methods Using a retrospective analysis method,the study objects were 64 STEMI patients admitted to Qinghai Province Cardiovascular and Cerebrovascular Disease Specialty Hospital from June 2018 to June 2019.All patients were tested for serum perilipin-5 levels on the second day of admission,and based on perilipin-5 The expression level was divided into low expression group(<3.12μg/L)and high expression group(>3.12μg/L),32 cases in each;the two groups of patients were compared the degree of coronary artery disease,and the serum of patients who died and survived within 1 year perilipin-5 level,the incidence of adverse cardiovascular events and mortality within 1 year of follow-up.Results The vascular disease rate of 3 animals in the low expression group(33.33%)was significantly higher than that in the high expression group(4.17%),and the difference was significant(P<0.05).The expression level of serum perilipin-5 in patients who died within 1 year[(1.69±0.32)μg/L]was significantly lower than that of surviving patients[(4.07±0.81)μg/L],and the difference was significant(P<0.05).The mortality rate(15.63%,18.75%,25.00%,37.50%)of the low expression group at 1 week,1 month,6 months and 1 year was significantly higher than that of the high expression group(0,3.13%,6.25%,12.50%),The difference was significant(P<0.05).The incidence of adverse cardiovascular events(21.88%,31.25%,40.63%,56.25%)in the low expression group for 1 week,1 month,6 months and 1 year was significantly higher than that of the high expression group(3.13%,6.25%,9.38)%,15.63%,the differences were all significant(P<0.05).Conclusion The expression level of serum perilipin-5 is significantly related to the short-term and long-term prognosis of STEMI patients and the degree of coronary artery disease.The lower the expression level of serum perilipin-5,the worse the prognosis.