葛根治疗项痹古今研究概述

Overview of Ancient and Modern Studies on Gegen(Pueraria Lobata)for Treating Neck Impediment

梳理古今医家对葛根治疗项痹(颈椎病)作用的认识,并总结现代研究在葛根治疗项痹作用机制和疗效方面的进展。有关葛根治疗项痹的记载最早见于东汉时期张仲景的著作《伤寒论》,之后不同历史时期的医家对葛根治疗项痹作用的认识逐渐变化。现代研究发现,葛根治疗颈椎病的主要活性单体是葛根素。葛根素通过减轻炎症反应、抑制破骨细胞增殖、增强成骨细胞活力等减缓颈椎病发展过程中颈椎骨性结构的退变,同时保护周围神经,减轻颈椎病所致的慢性疼痛。参考文献52篇。

To summarize the understanding of ancient and modern doctors on the effect of Gegen(Pueraria Lobata)in the treatment of neck impediment(cervical spondylosis),and summarize the progress of modern studies on the mechanism and efficacy of Gegen in the treatment of neck impediment.The earliest records about Gegen for treatment of neck impediment can be seen in ZHANG Zhongjing’s book Treatise on typhoid and miscellaneous diseases in the Eastern Han Dynasty.After that,doctors in different historical periods had gradually changed their understanding of Gegen for treatment of neck impediment.Modern studies have found that puerarin is the main active monomer in the treatment of cervical spondylosis.Puerarin can reduce the degeneration of cervical bone structure during the development of cervical spondylosis by alleviating inflammatory response,inhibiting osteoclast proliferation and enhancing the activity of osteoblasts.At the same time,it can protect the peripheral nerves and alleviate the chronic pain caused by cervical spondylosis.There are 52 references.