急性脑梗死与糖尿病的相关性

The Correlation Between Acute Cerebral Infarction and Diabetes

目的探究急性脑梗死(ACI)与2型糖尿病(T2DM)的相关性。方法选取急性脑梗死合并2型糖尿病患者41例作为观察组,在我院于2016年1月—2019年9月进行诊断治疗,并选择同期36例单纯急性脑梗死(不伴2型糖尿病)患者作为对照组,对比两组的血清学指标及颈动脉内膜中层厚度(IMT)、血糖波动参数指标及NIHSS评分,以及多元线性回归分析NIHSS评分与各因素的情况。结果相较于对照组,观察组的HDL-C无显著变化(P>0.05),但是Hcy、HbAlc、IMT、TG、LDL-C、TC显著升高,对比差异有统计学意义(P<0.05);相较于对照组,观察组的MBG、NIHSS、LAGE评分均显著升高,对比有统计学意义(P<0.05);LDL-C、Hcy、IMT、NIHSS评分和MAGE呈正相关,(r=0.632、0.859、0.735,P<0.05);LDL-C、Hcy、IMT、MAGE和NIHSS呈正相关,(r=0.603、0.814、0.903、0.955,均为P<0.05)。结论合并有2型糖尿病的急性脑梗死患者在第1周内,NIHSS评分升高,LDL-C、Hcy、IMT、MAGE和NIHSS呈正相关,Hcy、Hb Alc、IMT、TG、LDL-C、TC显著升高,具有临床应用价值。

Objective To explore the correlation between acute cerebral infarction(ACI)and type 2 diabetes mellitus(T2 DM).Methods 41 cases of acute cerebral infarction with type 2 diabetes were selected as the observation group,and the diagnosis and treatment were performed in our hospital from January 2016 to September 2019,and 36 cases of simple acute cerebral infarction(without type 2 diabetes)were selected as the control group.The serum and carotid intima-media-thickness(IMT),the parameters of blood glucose fluctuation and the NIHSS score of the two groups were compared,and the scores of NIHSS and the factors were analyzed by multiple linear regression.Results Compared with the control group,the HDL-C of the observation group did not change significantly.However,Hcy,HbAlc,IMT,TG,LDL-C and TC were significantly increased(P<0.05);compared with the control group,MBG,NIHSS and LAGE scores of the observation group were significantly increased(P<0.05);and the LDL-C,Hcy,IMT,NIHSS score was positively correlated with MAGE(r=0.632,0.859,0.735,P<0.05).There was a positive correlation between LDL-C,Hcy,IMT,MAGE and NIHSS(r=0.603,0.814,0.903,0.955,all P<0.05).Conclusion Patients with acute cerebral infarction with type 2 diabetes had a positive correlation between NIHSS score,LDL-C,Hcy,IMT,MAGE and NIHSS in the first week,and the NIHSS score,Hcy,HbAlc,IMT,TG,LDL-C,TC were significantly increased,which had clinical application value.