血小板在脓毒症中的关键作用

Key role of platelets in sepsis

脓毒症是危重症患者死亡的主要原因之一,由宿主对入侵病原体的有害反应引起的。脓毒症主要涉及炎症反应和凝血激活两个关键的机制,近年来研究发现血小板不仅在止血和伤口愈合方面发挥着作用,也在固有性免疫和适应性免疫方面发挥着重要的作用,同时,还是局部和全身炎症反应的促进者、组织器官损伤的参与者,血小板的这些功能使其在脓毒症的发生发展中发挥了关键的作用。

Sepsis is one of the main causes of death in critically ill patients,which is caused by the host’s harmful reaction to invasive pathogens.Sepsis mainly involves two key mechanisms:inflammation and coagulation activity.In recent years,studies have found that platelets not only play a role in hemostasis and wound healing,but also plays an important role in innate immunity and adaptive immunity.At the same time,it is also a promoter of local and systemic inflammation and a participant in tissue and organ injury.These functions of platelets play a key role in the occurrence and development of sepsis.