培土生金法对新冠肺炎肺脾气虚证患者免疫功能和炎症指标的影响

The Effect of Peitu Shengjin Method on the Immune Function and Inflammatory Indexes of Patients with the Syndrome of Qi Deficiency of Lung and Spleen of COVID-19

目的:观察培土生金法治疗新型冠状病毒肺炎(corona virus disease 2019,COVID-19)肺脾气虚证患者的临床疗效及其对免疫功能和炎症指标的影响。方法:将69例COVID-19确诊患者按照治疗意愿分为中西医治疗组(研究组)47例和单纯西医治疗组(对照组)22例。对照组采用常规抗病毒治疗,研究组在对照组的基础上加用肺脾气虚汤,连续治疗10 d后,比较两组患者的临床疗效,免疫球蛋白M(immunoglobulin M,IgM)抗体、IgG抗体等免疫指标,C-反应蛋白(C-reactive protein,CRP)、白细胞介素-6(interleukin 6,IL-6)等炎症因子,白细胞计数、淋巴细胞计数、中性粒细胞计数、红细胞沉降率(erythrocyte sedimentation rate,ESR)等感染指标,谷氨酸-丙酮酸转氨酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、血清总蛋白(serum total protein,STP)、血尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,Scr)、血尿酸(blood uric acid,BUA)等肝肾功能指标。结果:研究组临床有效率显著高于对照组(P<0.05);治疗后,研究组患者的IgM抗体、IgG抗体、CRP、IL-6、ESR显著降低,且优于对照组患者(P<0.05)。结论:培土生金法治疗COVID-19肺脾气虚证疗效显著,可减轻患者的炎性反应,改善免疫功能,利于恢复。

Objective:To observe the clinical efficacy of Peitu Shengjin method in the treatment of patients with the syndrome of qi deficiency of lung and spleen of corona virus disease 2019(COVID-19)and its influence on immune function and inflammation indicators.Methods:The 69 patients with confirmed COVID-19 were divided into Chinese and Western medicine treatment group(research group)with 47 cases and Western medicine treatment group(control group)with 22 cases according to their treatment wishes.The control group was treated with conventional antiviral therapy,and the study group was treated with Feipei Qixu Decoction on the basis of the control group.After continuous treatment for 10 days,the clinical efficacy of the two groups of patients,IgM antibodies,IgG antibodies and other immune indicators,C-reactive protein(CRP),interleukin 6(IL-6)and other inflammatory factors,white blood cells count,lymphocyte count,neutrophil count,Erythrocyte sedimentation rate(ESR)and other infection indicators,Alanine aminotransferase(ALT),Aspartate aminotransferase(AST),Serum total protein(STP),Blood urea nitrogen(BUN),Serum creatinine(Scr),Blood uric acid(BUA)and other liver and kidney function indicators were compared.Results:The clinical effective rate of the research group was significantly higher than that of the control group(P<0.05);after treatment,the IgM antibody,IgG antibody,CRP,IL-6,and ESR of the research group were significantly lower than those in the control group(P<0.05).Conclusion:The treatment of COVID-19 with the syndrome of qi deficiency of lung and spleen by Peitu Shengjin method is effective,which can alleviate the inflammatory response of patients,improve immune function,and facilitate recovery.