清肺排毒汤在新冠肺炎气阴两虚证患者恢复期治疗中的应用

The Application Effect of Qingfei Paidu Decoction in the Treatment of Patients with COVID-19 with the Syndrome of Deficiency of Both Qi and Yin

目的:探讨清肺排毒汤在新型冠状病毒肺炎气阴两虚证患者恢复期治疗中的应用价值。方法:选取2020年7月至2020年9月于新疆维吾尔自治区第六人民医院隔离治疗的42例普通型新型冠状病毒肺炎患者作为观察组,中医辨证为气阴两虚证,患者在常规抗病毒治疗基础上联合应用清肺排毒汤治疗,另选取2020年5月至2020年9月同期仅接受常规抗病毒治疗的30例普通型新型冠状病毒肺炎患者作为常规组。对比两组患者治疗前后中医证候积分及血生化、免疫功能指标改善情况。结果:两组患者均顺利完成治疗,无死亡病例。观察组首次核酸转阴时间、住院时间明显低于常规组,差异有统计学意义(P<0.05);治疗前两组发热、乏力、咽干、咽痛等中医证候积分比较,差异无统计学意义(P>0.05),治疗后均较治疗前明显降低(P<0.05),但观察组治疗后各证候积分明显低于常规组,差异有统计学意义(P<0.05);随着治疗时间的延伸,两组白细胞(white blood cell,WBC)、血小板(platelet,PLT)呈先升高后降低趋势,而淋巴细胞计数(lymphocyte,LYM)呈先降低后升高趋势;治疗前两组T淋巴细胞亚群(CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+))比较,差异无统计学意义(P>0.05),治疗后CD_(3)^(+)、CD_(4)^(+)均较治疗前明显升高,且观察组治疗后CD_(3)^(+)、CD_(4)^(+)明显高于常规组,差异有统计学意义(P<0.05),但两组治疗前后CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)比较,差异无统计学意义(P>0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规西医抗病毒治疗基础上联合清肺排毒汤,可显著改善新型冠状病毒肺炎气阴两虚证患者临床症状与体征,疗效较为理想且安全可靠。

Objective:To explore the application value of Qingfei Paidu Decoction in the treatment of convalescent patients with corona virus disease 2019(COVID-19)of the syndrome of deficiency of both qi and yin.Methods:42 patients with common COVID-19 who were isolated in the Sixth People's Hospital of Xinjiang Uygur Autonomous Region from July 2020 to September 2020 were selected as the observation group.TCM syndrome differentiation is the syndrome of deficiency of both qi and yin.The patients were treated with Qingfei Paidu Decoction on the basis of routine antiviral treatment.Another 30 patients with common COVID-19 who only received conventional antiviral therapy from May 2020 to September 2020 were selected as the conventional group.The improvement of TCM syndrome score,blood biochemical and immune function indexes were compared before and after treatment.Results:The two groups of patients successfully completed the treatment,and no deaths occurred;the first nucleic acid conversion time and hospitalization time of the observation group were significantly lower than those of the routine group,and the difference was statistically significant(P<0.05);there was no significant difference in the scores of TCM syndromes in the two groups before treatment for fever,fatigue,dry throat,and sore throat(P>0.05),and the scores were significantly lower after treatment than before treatment(P<0.05),but the scores for each symptom after treatment in the observation group were obvious lower than the conventional group,andthe difference is statistically significant(P<0.05);with the extension of treatment time,the White blood cell(WBC)and Platelet(PLT)of the two groups increased first and then decreased,while the Lymphocyte count(LYM)decreased first and then increased.Before treatment,there was no statistically significant difference between the two groups of T lymphocyte subsets(CD_(3)^(+),CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+))(P>0.05).After treatment,CD_(3)^(+)and CD_(4)^(+)were significantly higher than before treatment.After treatment,CD_(3)^(+)and CD_(4)^(+)in the observation group were significantly higher than those in the conventional group.The difference was statistically significant(P<0.05).However,the comparison of CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+)between the two groups before and after treatment.The difference was not statistically significant(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:On the basis of conventional western medicine antiviral treatment,the combination of Qingfei Paidu Decoction can significantly improve the clinical symptoms and signs of patients with COVID-19 with the syndrome of deficiency of both qi and yin.The curative effect is relatively ideal and safe and reliable.