活血化瘀兼清热解毒方治疗脑缺血临床用药特点分析

Analysis of Clinical Medication Characteristics of Huoxue Huayu Prescriptions Combined with Qingre Jiedu Prescriptions in the Treatment of Cerebral Ischemia

目的:探究活血化瘀兼清热解毒方治疗脑缺血的用药特点,为脑缺血的治疗用药提供理论参考。方法:以国内外数据库作为数据来源,以全文含有活血化瘀兼清热解毒方和脑缺血进行文献搜索,剔除动物实验类、综述类和个案报道等文献,筛选临床治疗脑缺血的活血化瘀兼清热解毒方剂,各药录入Excel表,采用统计软件SPSS Statistics 22.0和SPSS Clementine 12.0对数据进行统计处理和关联规则分析。结果:在纳入的57个活血化瘀兼清热解毒方剂中涉及107味中药,累积出现频数最高的前3位中药:红花(41次,71.93%)、川芎(40次,70.18%)和赤芍(35次,61.40%)。使用最多的前3类中药:活血化瘀药(188次,37.76%)、补虚药(81次,16.70%)和清热药(51次,10.52%)。四气常以温(178次,36.70%)、平(120次,24.74%)为主;五味主要集中在苦(203次,30.21%)、甘(195次,29.02%);归经主要作用于肝经(376次,34.85%)、脾经(143次,13.25%)、肺经(120次,11.12%)。活血化瘀兼清热解毒方抗脑缺血的药理作用特点主要为改善神经功能(12次,21.05%)、抑制血小板聚集率(11次,19.30%)和抗炎(8次,14.04%)。关联规则分析发现,16个关联较高的药对组合,因子分析和系统聚类分析分别得到5个公因子和5个聚类。结论:活血化瘀兼清热解毒方对于脑缺血的治疗,多以活血化瘀药和清热药为主,多选择性温、味甘和入肝经的中药。数据挖掘统计为临床中药配伍提供理论依据,为指导临床用药提供科学基础。

Objective:To explore the characteristics of Huoxue Huayu prescriptions combined with Qingre Jiedu prescriptions in the treatment of cerebral ischemia,and to provide theoretical reference for the treatment of cerebral ischemia.Methods:Using domestic and foreign databases as data sources,literature search was carried out with full text of Huoxue Huayu prescriptions combined with Qingre Jiedu prescriptions and cerebral ischemia.Animal experimental literature,review literature and case reports were excluded,and clinical application of Huoxue Huayu prescriptions combined with Qingre Jiedu prescriptions for cerebral ischemia was screened.All medicinals were entered into Excel.SPSS Statistics 22.0 and SPSS Clementine 12.0 were used to process the data and analyze the association rules.Results:Among the 57 Huoxue Huayu prescriptions combined with Qingre Jiedu prescriptions,involving 107 Chinese medicinals,the top three Chinese medicinals with the highest cumulative frequency are:Honghua(Flos Carthami)(41 times,71.93%),Chuanxiong(Rhizoma Ligustici Chuanxiong)(40 times,70.18%)and Chishao(Radix Paeoniae Rubra)(35 times,61.40%).The top three kinds of Chinese medicinals used most were:Huoxue Huayumedicinals(188 times,37.76%),Buxu medicinals(81 times,16.70%)and Qingre medicinals(51 times,10.52%).The four nature of Chinese medicinals were mainly warm(178 times,36.70%)and mild(120 times,24.74%).The main five flavors were bitter(203 times,30.21%)and sweet(195 times,29.02%).Meridian tropism mainly affected liver meridian(376 times,34.85%),spleen meridian(143 times,13.25%)and lung meridian(120 times,11.12%).The main pharmacological effects of Huoxue Huayu prescriptions combined with Qingre Jiedu prescriptions on cerebral ischemia were improving neurological function(12 times,21.05%),inhibiting platelet aggregation rate(11 times,19.30%)and anti-inflammatory(8 times,14.04%).Association rule analysis found 16 compatibility of couplet medicines with high association.Factor analysis and cluster analysis obtained 5 common factors and 5 clusters respectively.Conclusion:In the treatment of cerebral ischemia,Huoxue Huayu prescriptions combined with Qingre Jiedu prescriptions are mainly composed of Huoxue Huayu and Qingre medicinals,and the medicinals with warm,sweet nature and entering the liver meridian are mostly selected.Data mining statistics provide a theoretical basis for clinical compatibility of Chinese medicine,and provide a scientific basis for guiding clinical medication.