利拉鲁肽对睡眠呼吸暂停综合征合并2型糖尿病睡眠的影响

The Effect of Liraglutide on Sleep Apnea Syndrome with Type 2 Diabetes

目的探讨利拉鲁肽对睡眠呼吸暂停综合征合并2型糖尿病睡眠的影响。方法选择2019年1月—2020年6月该院收治的阻塞性睡眠呼吸暂停综合征合并2型糖尿病患者80例,对照组使用二甲双胍片,观察组使用利拉鲁肽,比较两组睡眠过程中血氧饱和度变化情况,睡眠呼吸暂停监测主要指标变化情况,干预1疗程后睡眠呼吸暂停和夜间周期性腿动情况,治疗前后空腹血糖水平。结果睡眠监测过程中,观察组睡眠前30 min、快动眼睡眠过程中、慢动眼睡眠过程中和苏醒前30 min血氧饱和度水平均明显高于对照组,差异有统计学意义(P<0.05),观察组睡眠呼吸暂停监测主要指标中AI、OAI水平均显著小于对照组,差异有统计学意义(P<0.05),干预后1疗程后,观察组睡眠呼吸暂停显著少于对照组,差异有统计学意义(P<0.05),且夜间周期性腿动发生比例低于对照组,差异有统计学意义(P<0.05),治疗后观察组空腹血糖水平低于治疗前及治疗后对照组,差异有统计学意义(P<0.05)。结论针对睡眠呼吸暂停综合征合并2型糖尿病者,使用利拉鲁肽治疗,能有效减少夜间缺氧,改善睡眠质量,减少睡眠呼吸暂停严重程度。

Objective To investigate the effect of liraglutide on sleep apnea syndrome with type 2 diabetes.Methods A total of 80 patients with obstructive sleep breathing syndrome and type 2 diabetes who were admitted to the hospital from January 2019 to June 2020 were selected.The control group was treated with metformin tablets and the observation group was treated with liraglutide.The changes in blood oxygen saturation during sleep between the two groups,the changes in main indicators of sleep apnea monitoring in the two groups,sleep apnea and periodic leg movements at night after 1 course of intervention between the two groups,and fasting blood glucose levels before and after treatment were compared.Results During sleep monitoring,30 min before sleep,rapid eye movement sleep,slow eye movement sleep,and 30 min before waking up the blood oxygen saturation level of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).The observation group had sleep breathing AI and OAI levels in the main indicators of suspension monitoring were significantly lower than those in the control group,the difference was statistically significant(P<0.05).After 1 course of treatment,the observation group had significantly less sleep apnea than the control group,the difference was statistically significant(P<0.05),and periodic leg movements occurrance rate at night was lower than that of the control group,the difference was statistically significant(P<0.05),and the fasting blood glucose level of the observation group after the intervention was lower than that of the control group before and after the intervention,the difference was statistically significant(P<0.05).Conclusion For patients with sleep apnea syndrome and type 2 diabetes,treatment with liraglutide can effectively reduce night hypoxia,improve sleep quality,and reduce the severity of sleep apnea.