心衰合剂联合美托洛尔对慢性心力衰竭患者的临床疗效

Clinical effect of heart failure mixture combined with metoprolol on patients with chronic heart failure

目的:探究心衰合剂联合美托洛尔对慢性心力衰竭患者的临床疗效。方法:将104例慢性心力衰竭患者按照不同治疗方案分为A组(n=52,美托洛尔治疗)、B组(n=52,美托洛尔+心衰合剂治疗)。治疗2个月后,比较两组患者疗效、心功能指标及生活质量差异。结果:治疗后,A组临床总有效率(71.15%)低于B组(88.46%)(P<0.05);两组左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室收缩末期容积(LVESV)、N末端B型脑钠尿肽前体(NT-proBNP)、心肌肌钙蛋白(CTn-I)、中医证候积分、生活质量问卷(MLHFQ)评分低于治疗前,而其左心室射血分数(LVEF)水平高于治疗前(P<0.05),且B组上述指标的改善程度优于A组(P<0.05)。结论:心衰合剂联合美托洛尔治疗慢性心力衰竭的临床疗效较显著,患者的心功能及生活质量得到提升。

Objective:To investigate the clinical effect of heart failure mixture combined with metoprolol on patients with chronic heart failure.Methods:A total of 104 patients with chronic heart failure were divided into group A(n=52,metoprolol)and group B(n=52,metoprolol+heart failure mixture)according to different treatments.After 2 months of treatment,the efficacy,cardiac function index and quality of life were compared between the two groups.Results:After treatment,the total clinical effective rate of group A(71.15%)was significantly lower than that of the group B(88.46%,P<0.05).Besides,the left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left ventricular end systolic volume(LVESV),N-terminal pro brain natriuretic peptide(NT proBNP),cardiac troponin(CTn-I),TCM syndrome score and quality of life questionnaire(MLHFQ)scores of the two groups were obviously lower than those before treatment(P<0.05),while the left ventricular ejection fraction(LVEF)level was notably higher than that before treatment(P<0.05).Also,the improvement of the above indexes in group B was significantly better than that in group A(P<0.05).Conclusion:Heart failure mixture combined with metoprolol in the treatment of chronic heart failure effectively improve the clinical efficacy of heart failure,improve patients'heart function and quality of life.