摘要
慢性阻塞性肺疾病(COPD)简称慢阻肺,是一种严重危害人类健康的慢性呼吸系统疾病,具有高患病率、高致残率和高病死率的特点。骨骼肌功能障碍是COPD常见的肺外并发症,可致临床急性加重,使患者生活质量下降、病死率升高,但目前COPD并发骨骼肌功能障碍的分子机制尚不明确。该文就近年来国内外对COPD并发骨骼肌功能障碍的分子机制研究进展进行综述,以期为潜在的治疗及研究方向提供参考。
Chronic obstructive pulmonary disease(COPD)is a disease with high prevalence,high disability and high mortality,which endangers patients'health seriously.As a common extrapulmonary complication of COPD,skeletal muscle dysfunction leading to the decline of life quality,and increase of mortality,as well as the acute exacerbation of COPD.Howerer,the molecular mechanism of skeletal muscle dysfunction is unclear.This article reviews the potential molecular mechanisms of skeletal muscle dysfunction caused by COPD to provide certain reference value for clinical diagnosis and treatment.
作者
田园园
范正媛
杨曙光
杨建雅
王明航
李素云
Tian Yuan-Yuan;Fan Zheng-Yuan;Yang Shu-Guang;Yang Jian-Ya;Wang Ming-Hang;Li Su-Yun(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450046,China;Department of Respiratory and Critical Medicine,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450003,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2021年第4期386-392,共7页
Medical Journal of Chinese People's Liberation Army
基金
国家重点研发计划(2018YFC1704801)
中原千人计划(202101510002)
河南省中医药科学研究专项课题(2018JDZX102)。
关键词
慢性阻塞性肺疾病
骨骼肌功能障碍
分子机制
chronic obstructive pulmonary disease
skeletal muscle dysfunction
molecular mechanism