慢性阻塞性肺疾病并发骨骼肌功能障碍的分子机制研究进展

Research progress on the mechanism of skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease

慢性阻塞性肺疾病(COPD)简称慢阻肺,是一种严重危害人类健康的慢性呼吸系统疾病,具有高患病率、高致残率和高病死率的特点。骨骼肌功能障碍是COPD常见的肺外并发症,可致临床急性加重,使患者生活质量下降、病死率升高,但目前COPD并发骨骼肌功能障碍的分子机制尚不明确。该文就近年来国内外对COPD并发骨骼肌功能障碍的分子机制研究进展进行综述,以期为潜在的治疗及研究方向提供参考。

Chronic obstructive pulmonary disease(COPD)is a disease with high prevalence,high disability and high mortality,which endangers patients'health seriously.As a common extrapulmonary complication of COPD,skeletal muscle dysfunction leading to the decline of life quality,and increase of mortality,as well as the acute exacerbation of COPD.Howerer,the molecular mechanism of skeletal muscle dysfunction is unclear.This article reviews the potential molecular mechanisms of skeletal muscle dysfunction caused by COPD to provide certain reference value for clinical diagnosis and treatment.