超声弹性成像技术预测自发性早产:Meta分析

Ultrasonic elastography in predicting of spontaneous preterm birth:Meta-analysis

目的应用Meta分析评价超声弹性成像技术对自发性早产的预测价值。方法检索PubMed、Cochrane Library、中国知网及万方医学网自1990年1月1日—2020年1月1日收录的超声弹性成像预测早产相关文献,按照纳入及排除标准进行筛选,并评价其质量。采用Meta-disc 1.4软件进行Meta分析。结果最终纳入9篇文献、共1755名受试者,超声弹性成像预测早产的合并敏感度、合并特异度、合并阳性似然比、合并阴性似然比、合并诊断比值比及其95%CI分别为0.66[95%CI(0.60,0.71)]、0.78[95%CI(0.75,0.80)]、4.55([95%CI(1.94,10.67)]、0.36[95%CI(0.21,0.61)]及15.30[95%CI(5.85,39.99)],综合受试者工作特征曲线下面积(AUC)=0.8786,Q*=0.8091。结论超声弹性成像技术对预测自发性早产有一定价值。

Objective To explore the value of elastography for predicting preterm labor with meta analysis.Methods PubMed,Cochrane Library,CNKI and Wanfang Med Online were searched from January 1,1990 to January 1,2020.The literature on prediction of preterm birth with ultrasonic elastography were screened according to the inclusion and exclusion criteria,and the quality of articles were evaluated.Meta-disc 1.4 software was used for data analysis.Results Nine studies with a total of 1755 subjects were included.The combined sensitivity,combined specificity,combined positive likelihood ratio,combined negative likelihood ratio,combined diagnostic ratio and 95%CI of ultrasound elastography in predicting spontaneous preterm birth was 0.66(95%CI[0.60,0.71]),0.78(95%CI[0.75,0.80]),4.55(95%CI[1.94,10.67]),0.36(95%CI[0.21,0.61])and 15.30(95%CI[5.85,39.99]),respectively,and the area under total receiver operating characteristic curve(AUC)was 0.8786,Q*=0.8091.Conclusion Ultrasonic elastography had certain value in predicting preterm birth.