替格瑞洛和氯吡格雷治疗不稳定型心绞痛的疗效及成本-效果分析

Efficacy and Cost-Effectiveness Analysis of Ticagrelor and Clopidogrel in the Treatment of Unstable Angina Pectoris

目的:旨在分析替格瑞洛和氯吡格雷治疗不稳定型心绞痛的疗效及成本-效果。方法:选取2018年6月~2019年6月于本院心内科就诊的108例不稳定型心绞痛患者作为研究对象,将其随机分成氯吡格雷组和替格瑞洛组,各54例。在常规治疗基础上,氯吡格雷组予以氯吡格雷治疗,替格瑞洛组予以替格瑞洛治疗。比较两组临床疗效、成本-效果以及不良反应发生情况。结果:替格瑞洛组总有效率(92.59%)高于氯吡格雷组(81.48%),有统计学差异(P<0.05);替格瑞洛组成本-效果比(33.08)低于氯吡格雷组(40.41);两组均未发生严重不良反应。结论:替格瑞洛治疗不稳定型心绞痛的疗效更好,成本-效果更优。

Objective:To analyze the cost-effectiveness of ticagrelor and clopidogrel in the treatment of unstable angina pectoris.Methods:108 patients with unstable angina pectoris treated in the department of cardiology of our hospital from June 2018 to June 2019 were randomly divided into clopidogrel group and ticagrelor group,with 54 cases in each group.Based on the routine treatment,clopidogrel was used in clopidogrel group and ticagrelor was used in ticagrelor group.The therapeutic effects,cost-efficacy and adverse reactions of the two groups were compared.Results:The total effective rate of ticagrelor group(92.59%)was higher than that of clopidogrel group(81.48%),with statistical difference(P<0.05).The cost-effectiveness of the ticagrelor group(33.08)was lower than that of the clopidogrel group(40.41).Severe adverse reaction was not found in both groups.Conclusion:Ticagrelor is more effective and cost-efficient in the treatment of unstable angina pectoris.