缩宫素联合葡萄糖酸钙治疗产后出血临床效果

Clinical efficacy of oxytocin combined with calcium gluconate for treating postpartum hemorrhage

目的:探讨缩宫素联合葡萄糖酸钙治疗产后出血的临床疗效及对产妇凝血的影响。方法:选取2018年1月—2020年6月在本院分娩并诊断为产后出血产妇98例,随机分为对照组和观察组各49例,对照组采用缩宫素治疗,观察组采用缩宫素联合葡萄糖酸钙治疗,比较两组的临床疗效。结果:治疗后观察组有效率(91.9%)高于对照组(83.7%),凝血指标活化部分凝血活酶时间(APTT)(26.9±3.1s)、凝血酶原时间(PT)(11.1±0.2s)、D二聚体(D-D)(1.6±0.2 mg/L)低于对照组(28.2±3.4s、12.1±0.3s、1.6±0.2 mg/L),血浆纤维蛋白原(Fib)(4.5±0.7 g/L)高于对照组(4.1±0.6 g/L),产后2h(173.6±16.6 ml)和24h出血量(326.2±46.7 ml)、产后出血总量(499.8±31.6 ml)少于对照组(218.4±20.5 ml、486.5±32.8 ml、704.9±26.7 ml),氧化应激反应指标低于对照组,血钙、血红蛋白高于对照组,炎症因子低于对照组(均P<0.05)。结论:缩宫素联合葡萄糖酸钙治疗产后出血效果显著。

Objective: To explore the clinical efficacy of oxytocin combined with calcium gluconate for treating postpartum hemorrhage of women, and to study its influence on their coagulation function. Methods: 198 women with postpartum hemorrhage were selected and were randomly divided into two groups(49 cases in each group) from January 2018 to June 2020. The women in the control group were treated by oxytocin, and the women in the study group were treated by oxytocin combined with calcium gluconate. The treatment efficiency of the women was compared between the two groups. Results: The effective rate of the women in the study group(91.9%) was significant higher than that(83.7%) of the women in the control group. The coagulation indexes,such as activated partial thromboplastin time(APTT) prothrombin time(PT), and D-dimer(D-D) of the women in the study group were 26.9±3.1 s, 11.1±0.2 s, and 1.6± 0.2 mg/L, which were significant lower than those(28.2±3.4 s, 12.1±0.3 s, and 1.6± 0.2 mg/L) of the women in the control group, but the plasma fibrinogen(FIB) of the women(4.5± 0.7 g/L) in the study group was significant higher than that(4.1± 0.6 g/L) of the women in the control group. The amount of 2 h postpartum bleeding, 24 h postpartum bleeding, and the total amount of postpartum bleeding of the women in the study group were 173.6± 16.6 ml, 326.2± 46.7 ml, and 499.8±31.6 ml, which were significant lower than those(218.4± 20.5 ml, 486.5±32.8 ml, and 704.9± 26.7 ml) of the women in the control group. The indexes of oxidative stress reaction and inflammatory factors levels of the women in the study group were significant lower than those of the women in the control group, but the serum calcium and hemoglobin levels of the women in the study group were significant higher(all P<0.05). Conclusion: Oxytocin combined with calcium gluconate for treating postpartum hemorrhage has significant effectiveness.