子痫前期患者血清sICAM-1、PAPP-A、VEGF表达及预测价值

Expression and predictive value of serum sICAM-1,PAPP-A and VEGF levels in preeclampsia

目的:研究子痫前期(PE)患者血清可溶性细胞间粘附分子-1(sICAM-1)、妊娠相关蛋白A(PAPP-A)、血管内皮生长因子(VEGF)表达水平与PE进程的相关性及预测价值。方法:选取2016年1月—2019年1月在本院常规产前检查的PE孕妇59例为病例组,并根据PE严重程度分为轻度PE组(36例)与重度PE组(23例),同期产前检查的正常孕妇30例为对照组,测定血清sICAM-1、PAPP-A、VEGF表达,分析各组表达水平差异以及与PE进程的相关性。结果:病例组血清sICAM-1、PAPP-A、VEGF水平高于对照组(P<0.05);sICAM-1和PAPP-A水平比较:重度PE组>轻度PE组>对照组,VEGF水平重度PE组<轻度PE组<对照组(均P<0.05);病例组血清sICAM-1、PAPP-A与PE严重程度呈正相关,VEGF与PE严重程度呈负相关(P<0.05);sICAM-1与PAPP-A呈正相关,与VEGF呈负相关,PAPP-A与VEGF呈负相关(P<0.05);sICAM-1、VEGF、PAPP-A预测PE敏感度和特异性分别为94.9%和93.3%、73.3%和98.3%、72.9%和93.3%。结论:sICAM-1、PAPP-A表达水平与PE病情严重程度呈正相关,VEGF与之呈负相关,三者预测PE效能较高,有望作为PE监测的依据。

Objective:To study the correlation between the expression levels of serum soluble intercellular adhesion molecule-1(sICAM-1),pregnancy associated plasma protein A(PAPP-A),and vascular endothelial growth factor(VEGF)of the pregnant women with severity of preeclampsia(PE),and to study their predictive value for PE.Methods:59 pregnant women with PE were selected in study group,which included 36 women with mild PE in group A,and 23 women with severe PE in group B.30 healthy pregnant women during the same period were randomly selected in control group.The expression of serum sICAM-1,PAPP-A and VEGF of the women in the three groups were measured.The different expressions of serum sICAM-1,PAPP-A and VEGF of these women were analyzed.The correlation between the expressions levels of serum sICAM-1,PAPP-A and VEGF and the severity of PE was analyzed.Results:The serum levels of SICAM-1,PAPP-A and VEGF of the women in the study group were significant higher than those of the women in the control group(P<0.05).The levels of sICAM-1 and PAPP-A of the women in group B were the highest,but those of the women in the control group were the lowest(P<0.05).The VEGF level of the women in group B was the lowest,but that of the women in the control group was the highest(P<0.05).The levels of sICAM-1 and PAPP-A were positively correlated with the severity of PE,but the VEGF level was negatively correlated with the severity of PE(P<0.05).In the study group,the serum sICAM-1 level was positively correlated with the PAPP-A level and was negatively correlated with the VEGF level,and the PAPP-A level was negatively correlated with the VEGF level(P<0.05).The sensitivity and the specificity of the sICAM-1 level for predicting PE were 94.9%and 93.3%,which of the VEGF level for predicting PE were 73.3%and 98.3%,and which of the PAPP-A level for predicting PE were 72.9%and 93.3%.Conclusion:The expression levels of serum sICAM-1 and PAPP-A are positively correlated with the severity of PE,while VEGF level is negatively correlated with the severity of PE.The efficiency of the expression levels of serum sICAM-1,PAPP-A,and PAPP-A for predicting PE is high,which is expected to be used as evidences for monitoring PE.