阿司匹林与2型糖尿病患者肌少症相关性的横断面研究

A cross-sectional survey on the correlation between Aspirin and sarcopenia in patients with type 2 diabetes mellitus

目的探讨阿司匹林与2型糖尿病患者肌少症的相关性。方法采用横断面调查方法,选取2013年6月~2015年12月重庆医科大学附属第一医院收治的939例2型糖尿病患者作为研究对象,按照是否服用阿司匹林分为阿司匹林组(504例)和非阿司匹林组(435例)。通过倾向性评分匹配法,对组间协变量进行评分匹配,采用单因素Logistic回归分析法分析阿司匹林与肌少症的相关性。结果939例2型糖尿病患者中,肌少症184例,患病率为19.6%。经对肌少症协变量(年龄、血红蛋白、体重指数、血尿酸、高密度脂蛋白胆固醇、三酰甘油、中性粒细胞百分比、糖尿病足、糖尿病神经病变)进行倾向性评分匹配后,阿司匹林组503例,非阿司匹林组307例。倾向性评分匹配前后,阿司匹林组肌少症的患病率均低于非阿司匹林组,差异有统计学意义(P<0.05)。结论2型糖尿病患者阿司匹林使用与肌少症发生相关,可能降低2型糖尿病患者肌少症患病率,需进一步临床研究的验证。

Objective To investigate the correlation between Aspirin and sarcopenia in patients with type 2 diabetes.Methods A cross-sectional survey was conducted in 939 patients with type 2 diabetes who were admitted to the First Affiliated Hospital of Chongqing Medical University from June 2013 to December 2015.Patients were divided into Aspirin group(504 cases)and non-Aspirin group(435 cases)according to whether they took aspirin or not.The covariates of the patients were matched by the propensity score matching method,and the correlation between Aspirin and sarcopenia was evaluated by univariate Logistic regression.Results Among the 939 patients with type 2 diabetes,184 patients(19.6%)had sarcopenia.Propensity score matching method was further used to match the covariates of sarcopenia(age,hemoglobin,body mass index,serum uric acid,high-density lipoprotein cholesterol,triglyceride,neutrophil percentage,diabetic foot,diabetic neuropathy),after matching,Aspirin group(503 cases)and non-Aspirin group(307cases).Before and after propensity score matching,the prevalence rate of sarcopenia in Aspirin group was lower than that in non-Aspirin group,and the difference was statistically significant(P<0.05).Conclusion Aspirin medication is associated with sarcopenia in patients with type 2 diabetes,which indicate that Aspirin may reduce the risk of sarcopenia.Further validation is required by clinical studies.