miRNA-34家族在宫颈癌中作用机制的研究进展

Research progress on the mechanism of miRNA-34 family in cervical cancer

宫颈癌是指原发于宫颈的恶性肿瘤,是威胁全球妇女健康最常见的恶性肿瘤之一,早期症状常不明显,尽管使用了先进的筛查手段和预防性疫苗,但是在发展中国家,其发病率及死亡率仍较高,因此需要寻找新的更有效的分子标记来进一步辅助宫颈癌的诊断、治疗和预后的评估。miRNA-34家族在肿瘤细胞的增殖、周期调控、凋亡以及衰老等过程中发挥着重要作用,是癌症分子靶向治疗研究的热点。本文总结了miRNA-34家族在恶性肿瘤中的分子作用机制,重点概述了宫颈癌中miRNA-34的作用及研究进展。

Cervical cancer is a malignant tumor that originates in the cervix.It is one of the most common malignant tumors that threaten women′s health in the world.Early symptoms are often not obvious.Despite using of advanced screening methods and preventive vaccines,the morbidity and mortality are still high in developing countries,so it is necessary to find new more effective molecular markers to further assist the diagnosis,treatment and prognosis cervical cancer.The miRNA-34 family plays an important role in the process of tumor cell proliferation,cycle regulation,apoptosis and aging,and it′s also a hotspot in cancer molecular targeted therapy.This article summarizes the molecular mechanism of miRNA-34 family in malignant tumors,and focuses on the role and research progress of miRNA-34 in cervical cancer.