醋酸泼尼松联合依托考昔治疗类风湿性关节炎的效果

Effect of Prednisone Acetate combined with Etoricoxib in the treatment of rheumatoid arthritis

目的探讨醋酸泼尼松联合依托考昔治疗类风湿性关节炎患者的效果。方法选取2018年4月~2020年4月辽宁省本溪市中心医院收治的60例类风湿性关节炎患者,采用随机数字表法分为两组,每组各30例。对照组给予醋酸泼尼松治疗,观察组给予醋酸泼尼松和依托考昔治疗,各治疗2周。比较两组治疗前、治疗后的炎症指标[红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)]、预后指标[环瓜氨酸肽(CCP)]及视觉模拟评分法(VAS)、生活质量评分(SF-36)。结果治疗后,观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后两组CRP、ESR、RF水平均低于治疗前,且观察组CRP、ESR、RF水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组VAS评分低于治疗前,且观察组VAS评分低于对照组,差异有统计学意义(P<0.05)。治疗后随访3个月,两组SF-36评分均高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组CCP水平均低于治疗前,且观察组CCP水平低于对照组,差异均有统计学意义(P<0.05)。结论醋酸泼尼松联合依托考昔可有效减轻类风湿性关节炎患者的炎症反应,改善预后指标及生活质量,进一步提高疗效。

Objective To explore the effect of Prednisone Acetate combined with Etoricoxib in the treatment of patients with rheumatoid arthritis.Methods A total of 60 patients with rheumatoid arthritis treated in Benxi Central Hospital of Liaoning Province were selected from April 2018 to April 2020.According to the random number table method,they were divided into two groups,with 30 cases in each group.The control group was given Prednisone Acetate for treatment,and the observation group was given Prednisone Acetate combined with Etoricoxib for treatment,treatment for 2 weeks each.The inflammatory indexes(erythrocyte sedimentation rate[ESR],C-reactive protein[CRP],rheumatoid factor[RF]),prognostic indexes(cyclic citrullinated peptide[CCP]),visual analogue scale(VAS),and quality of life score(SF-36)were compared between the both groups before and after treatment.Results After treatment,the total effective rate of the observation group was higher than that of the control group,with a statistical significant difference(P<0.05).After treatment,the levels of CRP,ESR,and RF in the two groups were lower than those before treatment,and the levels of CRP,ESR,and RF in observation group were lower than those in control group,with statistical significant differences(P<0.05).After treatment,the VAS scores of the two groups were lower than those before treatment,and the VAS score of the observation group was lower than that in control group,with statistical significant differences(P<0.05).Follow-up for 3 months after treatment,the SF-36 scores of the two groups were higher than those before treatment,and the SF-36 score of observation group was higher than that in control group,the differences were statistically significant(P<0.05).After treatment,the CCP levels of the two groups were lower than before treatment,and the CCP level of observation group was lower than that of control group,with statistical significant differences(P<0.05).Conclusion Prednisone Acetate combined with Etoricoxib can more effectively reduce the inflammatory response in patients with rheumatoid arthritis,improve the prognostic indicators and long-term quality of life,and further improve the effective rate of treatment.