艾司洛尔联合低剂量胺碘酮治疗冠心病合并心律失常患者的临床效果

Clinical effect of Esmolol combined with low-dose Amiodarone in the treatment of patients with coronary heart disease and arrhythmia

目的探讨艾司洛尔联合低剂量胺碘酮治疗冠心病合并心律失常患者的临床效果。方法选择沈阳市第五人民医院2017年8月~2019年8月收治的60例冠心病合并心律失常患者作为研究对象,按照治疗方法不同分为观察组(32例)与对照组(28例)。对照组采用单纯胺碘酮治疗,观察组在此基础上采用艾司洛尔联合治疗,比较两组患者的心功能指标、心电图指标及治疗效果。结果治疗前,患者的心功能指标组间比较,差异无统计学意义(P>0.05);治疗后,两组患者的左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)低于治疗前,左心室射血分数(LVEF)高于治疗前,差异有统计学意义(P<0.05);治疗后,观察组患者LVEDV、LVESV低于对照组,LVEF高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的心电图指标比较,差异无统计学意义(P>0.05);治疗后,两组患者的心率和Q-T间期值低于治疗前,差异有统计学意义(P<0.05);治疗后,观察组患者心率、Q-T间期值低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论艾司洛尔联合低剂量胺碘酮治疗冠心病合并心律失常,能发挥协同作用,有效改善患者心功能,疗效确切,是较为理想的用药方案。

Objective To explore the clinical effect of Esmolol combined with low-dose Amiodarone in the treatment of patients with coronary heart disease and arrhythmi.Methods From August 2017 to August 2019,a total of 60 cases of coronary heart disease with arrhythmia patients from the Fifth People′s Hospital of Shenyang were chosen as the research objects,they were divided into observation group(32 cases)and control group(28 cases)according to different treatment methods.The control group was treated with Amiodarone alone,on this basis,the observation group was treated with Esmolol,the cardiac function indexes,electrocardiogram indexes and treatment effect were compared between two groups.Results Before treatment,there was no statistically significant difference in cardiac function between the groups(P>0.05);after treatment,the left ventricular end-diastolic volume(LVEDV)and left ventricular end-systolic volume(LVESV)in two groups were lower than those before treatment,left ventricular ejection fraction(LVEF)was higher than that before treatment,the differences were statistically significant(P<0.05);after treatment,the LVEDV and LVESV in the observation group were lower than those in control group,and LVEF was higher than that in control group,the differences were statistically significant(P<0.05).Before treatment,electrocardiogram indexes of the two groups were compared,the differences were not statistically significant(P>0.05);after treatment,heart rate and Q-T interval values of two groups were lower than those before treatment,the differences were statistically significant(P<0.05);after treatment,heart rate and Q-T interval of observation group were lower than those in control group,the differences were statistically significant(P<0.05).The totla therapeutic effect of observation group was higher than that of control group,the difference was statistically significant(P<0.05).Conclusion Esmolol combined with low-dose Amiodarone in the treatment of coronary heart disease complicated with arrhythmia can play a synergistic effect,effectively improve the patient′s heart function,and has a definite effect.It is an ideal medication plan.