秋水仙碱、非布司他口服结合黄柏大黄外敷对老年急性痛风性关节炎患者的疗效观察

Clinical observation of Colchicine and Febuxostat combined with external application of Phellodendra and Rhubarb in elderly patients with acute gouty arthritis

目的探讨秋水仙碱、非布司他口服结合黄柏大黄外敷治疗老年急性痛风性关节炎患者的效果。方法选取2019年2月~2020年7月牡丹江医学院附属红旗医院收治的104例老年急性痛风性关节炎患者作为研究对象,采用随机数字表法将其分为对照组、观察Ⅰ组、观察Ⅱ组和观察Ⅲ组,每组各26例。对照组患者采用口服秋水仙碱治疗,观察Ⅰ组患者采用口服秋水仙碱和非布司他治疗,观察Ⅱ组患者采用口服秋水仙碱,外敷黄柏大黄治疗,观察Ⅲ组患者采用口服秋水仙碱和非布司他,同时外敷黄柏大黄治疗。治疗后,比较四组患者的关节周径差值、血尿酸水平和治疗效果。结果治疗后,观察Ⅰ组和观察Ⅱ组患者的关节周径差值小于对照组,观察Ⅲ组患者的关节周径差值小于对照组、观察Ⅰ组和观察Ⅱ组,差异有统计学意义(P<0.05);观察Ⅰ组和观察Ⅲ组患者的血尿酸水平均低于对照组和观察Ⅱ组,差异有统计学意义(P<0.05);观察Ⅲ组患者的总有效率高于对照组,差异有统计学意义(P<0.05)。结论秋水仙碱、非布司他口服结合黄柏大黄外敷可有效提高老年急性痛风性关节炎患者的治疗效果。

Objective To investigate the effect of Colchicine and Febuxostat combined with external application of Phellodendra and Rhubarb in the treatment of elderly patients with acute gouty arthritis.Methods A total of 104 elderly patients with acute gouty arthritis admitted to Hongqi Hospital Affiliated to Mudanjiang Medical University from February 2019 to July 2020 were selected as the research objects and divided into the control group,observationⅠ,Ⅱ,Ⅲgroup by random number table method,with 26 cases in each group.Control group was treated by oral colchicine treatment,observationⅠgroup was treated by oral Colchicine and Febuxostat,observationⅡgroup was treated by oral Colchicine combined with external application of Phellodendra and Rhubarb,observationⅢgroup was treated by oral Colchicine and Febuxostat combined with external application of Phellodendra and Rhubarb.After treatment,the difference of joint circumference,blood uric acid level and treatment effect of four groups were compared.Results After treatment,the joint diameter differences of the observationⅠ,Ⅱgroup were smaller than those of the control group,and the joint diameter difference of the observationⅢgroup was smaller than that of the control group,observationⅠ,Ⅱgroup,the differences were statistically significance(P<0.05).The levels of blood uric acid in observationⅠ,Ⅲgroup were lower than those in control group and observationⅡgroup,and the differences were statistically significant(P<0.05).The total effective rate of observationⅢgroup was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Oral Colchicine And Febuxostat combined with external application of Phellodendron and Rhubarb can effectively improve the therapeutic effect of elderly patients with acute gouty arthritis.