着色性干皮病并发鳞状细胞癌及基底细胞癌1例

A Case of Xeroderma Pigmentosum Complicated with Squamous Cell Carcinoma and Basal Cell Carcinoma

患者男,11岁,面颈部及四肢皮损10年,加重2年。面部广泛性溃疡及菜花状结节,眼、鼻及口唇严重损毁。曝光部位皮肤芝麻至黄豆大小褐色斑疹、斑丘疹及点状色素减退斑,前胸V字区可见数个黄豆至蚕豆大小的黑褐色结节,边缘隆起蜡样光泽性结节。结节及溃疡边缘组织病理示:基底细胞癌及鳞状细胞癌。结合患者病史、临床表现及组织病理学检查诊断:着色性干皮病并发鳞状细胞癌及基底细胞癌。

A 11-year-old male patient presented with skin lesions on the face and neck and four limbs for ten years,with aggravation for 2 years.Physical examination showed extensive facial ulcer and cauliflower-like nodule with serious damage to eyes,nose and lips.Brown spots,papules and punctate hypopigmentation spots with the sizes ranging from sesame to soybean sizes were observed on the exposed skin.Several black brown nodules about the size of soybean to broad bean could be seen in the V-shaped area of the anterior chest,with wax-like glossy nodules on the edge.Histopathological findings of the nodule and ulcerative lesions suggested basal cell carcinoma and squamous cell carcinoma.The final diagnosis of xeroderma pigmentosum complicated with squamous cell carcinoma and basal cell carcinoma was established according to the patient′s medical history,clinical manifestations and pathological examination.