瞬时受体电位离子通道与银屑病的研究进展

Research progress of transient receptor potential ion channels and psoriasis

银屑病的发生主要涉及细胞免疫系统异常及角质形成细胞增殖与分化异常等环节。近年研究发现多种瞬时受体电位(transient receptor potential,TRP)离子通道与银屑病发病有关,并在银屑病病理生理过程的多个环节中发挥重要作用。使用部分TRP通道的抑制剂或激活剂可以改善或缓解银屑病症状,提示部分TRP通道可能作为银屑病治疗的新靶点。本文主要对TRP通道与银屑病发病机制的关系及其作为银屑病治疗靶点的研究进展进行综述。

The occurrence of psoriasis mainly involves abnormal cellular immune system and the abnormal proliferation and differentiation of keratinocytes.Recent studies have found that transient receptor potential(TRP)ion channels are related to the etiology of psoriasis and play an important role in the pathophysiological process of psoriasis.Using inhibitors or activators of partial TRP channels can improve or alleviate the symptoms of psoriasis,suggesting that partial TRP channels may be new targets for psoriasis treatment.This article mainly reviews the relationship between TRP channels and etiology of psoriasis,and the research advancement of TRP channels as treatment targets for psoriasis.