法莫替丁与奥美拉唑治疗十二指肠溃疡的临床效果研究

Study on the clinical effect of famotidine and omeprazole in the treatment of duodenal ulcer

目的分析法莫替丁与奥美拉唑治疗十二指肠溃疡的临床效果。方法 72例十二指肠溃疡患者,采用信封法任意编号分为A组与F组,各36例。A组应用奥美拉唑治疗, F组应用法莫替丁治疗。比较两组患者的溃疡愈合时间、疼痛消失时间、住院时间、病情改善率、不良反应发生情况。结果 A组患者的溃疡愈合时间(9.42±1.03)d、疼痛消失时间(6.28±2.19)d、住院时间(8.02±1.03)d均短于F组的(12.75±2.49)、(8.43±3.52)、(11.04±2.06)d,差异均具有统计学意义(P<0.05)。A组患者的病情改善率为97.22%,高于F组的80.56%,差异具有统计学意义(P<0.05)。A组患者的不良反应发生率为8.33%,与F组的11.11%比较,差异无统计学意义(P>0.05)。结论奥美拉唑治疗十二指肠溃疡的效果优于法莫替丁,可促进患者症状的快速恢复,建议临床使用。

Objective To analyze the clinical effect of famotidine and omeprazole in the treatment of duodenal ulcer. Methods A total of 72 patients with duodenal ulcer were divided into group A and group F according to envelope method, with 36 cases in each group. Group A was treated with omeprazole, and group F was treated with famotidine. The ulcer healing time, pain disappearance time, hospitalization time, disease improvement rate and adverse reactions of the two groups were compared. Results The ulcer healing time, pain disappearance time, hospitalization time of group A were(9.42±1.03),(6.28±2.19) and(8.02±1.03) d, which were all shorter than(12.75±2.49),(8.43±3.52) and(11.04±2.06) d of group F, and the difference was statistically significant(P<0.05). The disease improvement rate of group A was 97.22%, which was higher than 80.56% of group F, and the difference was statistically significant(P<0.05). The incidence of adverse reactions of group A was 8.33%, which had no statistically significant difference compared with 11.11% of group F(P>0.05). Conclusion Omeprazole is better than famotidine in the treatment of duodenal ulcer, and can promote the rapid recovery of patients’ symptoms. It is recommended for clinical application.