加味芍药甘草汤颗粒制剂治疗肩关节撞击综合征Ⅲ期阴血亏虚证的疗效观察

Observation of efficacy of modified Shaoyao Gancao Decoction granules in the treatment of shoulder impingement syndrome with stage Ⅲ Yin blood deficiency syndrome

目的观察加味芍药甘草汤颗粒制剂治疗肩关节撞击综合征(SIS)Ⅲ期阴血亏虚证的临床疗效。方法 60例肩关节撞击综合征Ⅲ期阴血亏虚证患者,随机分成治疗组(29例)和对照组(31例)。治疗组给予加味芍药甘草汤颗粒制剂治疗,对照组给予塞来昔布和曲安奈德治疗。比较两组患者美国纽约特种外科医院评分系统(HSS)肩关节评分、临床疗效及安全性。结果治疗第7、10、175天,两组HSS肩关节评分均高于治疗第1天,差异有统计学意义(P<0.05);治疗第10、175天,两组HSS肩关节评分均高于治疗第7天,差异有统计学意义(P<0.05);治疗第175天,两组HSS肩关节评分均低于治疗第10天,差异有统计学意义(P<0.05);治疗第7天,对照组HSS肩关节评分(68.10±8.94)分高于治疗组的(58.00±6.86)分,差异有统计学意义(P<0.05);治疗第1、10、175天,两组HSS肩关节评分比较差异均无统计学意义(P>0.05)。治疗组治疗总有效率为96.6%,对照组为96.8%;两组治疗总有效率比较差异无统计学意义(P>0.05)。治疗过程中,治疗组及对照组均未发生血常规、肝肾功、心电图及生命体征异常。结论加味芍药甘草汤颗粒制剂治疗肩关节撞击综合征Ⅲ期阴血亏虚证患者的效果与塞来昔布加曲安奈德效果相同且安全,其为无创操作、颗粒制剂服用方便,对一些身体条件差伴有多种基础疾病不能耐受手术治疗的患者提供了新的方法。

Objective To observe the clinical efficacy of modified Shaoyao Gancao Decoction granules in the treatment of shoulder impingement syndrome(SIS) with stage Ⅲ Yin blood deficiency syndrome. Methods A total of 60 cases of shoulder impingement syndrome with stage Ⅲ Yin blood deficiency syndrome were randomly divided into treatment group(29 cases) and control group(31 cases). The treatment group was treated with modified Shaoyao Gancao Decoction granules, and the control group was treated with celecoxib and triamcinolone acetonide. The Hospital of Special Surgery(HSS) shoulder score, clinical efficacy and safety were observed and compared between the two groups. Results After 7, 10 and 175 days of treatment, the HSS shoulder scores of the two groups were all higher than those after 1 day of treatment, and the difference was statistically significant(P<0.05). After 10 and 175 days of treatment, the HSS shoulder scores of the two groups were all higher than those after 7 days of treatment, and the difference was statistically significant(P<0.05). After 175 days of treatment, the HSS shoulder scores of the two groups were all lower than those after 10 days of treatment, and the difference was statistically significant(P<0.05). After 7 days of treatment, the HSS shoulder score(68.10±8.94) points of the control group was higher than(58.00±6.86) points of the control group, and the difference was statistically significant(P<0.05). After 1, 10 and 175 days of treatment, there was no statistically significant difference in HSS shoulder score between the two groups(P>0.05). The total effective rate of the treatment group was 96.6%, which was 96.8% of the control group. There was no statistically significant difference in total effective rate between the two groups(P>0.05). During treatment, no abnormal blood routine, liver and kidney function, electrocardiogram and vital signs occurred in the treatment group and the control group. Conclusion Modified Shaoyao Gancao Decoction granules has the same effect as celecoxib and triamcinolone acetonide in treating shoulder impingement syndrome with stage Ⅲ Yin blood deficiency syndrome and is safe. It is a non-invasive operation, and the granule preparation is convenient to take, which is convenient to take, and provides a new method for some patients with poor physical conditions and a variety of underlying diseases who cannot tolerate surgical treatment.