舒血宁注射液联合瑞舒伐他汀在急性脑梗死患者中的应用研究

Application of Shuxuening injection combined with rosuvastatin on patients with acute cerebral infarction

目的探讨舒血宁注射液联合瑞舒伐他汀治疗急性脑梗死的疗效及对患者血浆基质金属蛋白酶-9(MMP-9)、肝细胞生长因子(HGF)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平及神经功能等的影响。方法分析2017年2月—2018年2月驻马店市中心医院收治的98例急性脑梗死患者临床资料,依据治疗方案不同分为对照组(瑞舒伐他汀治疗)和观察组(舒血宁注射液联合瑞舒伐他汀治疗),比较两组临床疗效、血浆MMP-9、HGF、TNF-α、IL-6水平,观察患者颈动脉斑块数量、斑块大小、斑块厚度、动脉内膜中层厚度(IMT)及药物安全性,CSS评分评估患者神经功能。结果治疗后观察组临床总有效率较对照组明显高(88.37%vs 69.05%,P<0.05);治疗前两组血浆MMP-9、HGF、TNF-α、IL-6水平、斑块数量、斑块大小、斑块厚度、IMT、CSS评分差异无统计学意义(P>0.05);与治疗前相较,治疗后两组血浆MMP-9、HGF、TNF-α、IL-6水平明显降低、斑块数量、斑块大小、斑块厚度、IMT明显减小,且治疗后观察组血浆MMP-9、HGF、TNF-α、IL-6水平、斑块数量、斑块大小、斑块厚度、IMT较对照组明显低、小,差异有统计学意义(P<0.05);治疗后1、3、5个月观察组CSS评分较对照组明显降低(P<0.05);治疗后两组不良反应总发生率相比较差异无统计学意义(23.26%vs 19.05%,χ^(2)=0.225,P>0.05)。结论舒血宁注射液联合瑞舒伐他汀治疗急性脑梗死的疗效明确,这与两者联合应用可有效减轻机体炎症反应、稳定斑块性质及恢复神经功能有一定关联,且有一定安全性。

Objective To investigate the efficacy of Shuxuening injection combined with rosuvastatin in the treatment of acute cerebral infarction and its influence on plasma matrix metalloproteinase-9(MMP-9),hepatocyte growth factor(HGF),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)levels and neurological function.Methods The clinical data of 98 patients with acute cerebral infarction in the hospital from February 2017 to February 2018 were retrospectively analyzed.According to different treatment regimens,they were divide into control group(rosuvastatin treatment)and observation group(shuxuening injection combined with rosuvastatin treatment).The clinical efficacy,plasma MMP-9,HGF,TNF-α,IL-6 levels of the two groups were compared,the number of carotid plaques,plaque size,plaque thickness,and intra-arterial membrane thickness(IMT)and drug safety were observed.CSS scores were used to assess neurological function in patients.Results After treatment,the total effective rate of the observation group was significantly higher than that of the control group(88.37%vs 69.05%,P<0.05).There were no significant differences in the levels of plasma MMP-9,HGF,TNF-α,IL-6,number of plaque,plaque size,plaque thickness,IMT,and CSS scores in the two groups before treatment(P>0.05).Compared with pre-treatment,levels of plasma MMP-9,HGF,TNF-α,IL-6 of the two groups were significantly decreased after treatment,plaque number,plaque size,plaques thickness and IMT were significantly decreased.After treatment,the levels of plasma MMP-9,HGF,TNF-α,IL-6,number of plaque,plaque size,plaque thickness and IMT in the observation group were significantly lower and smaller than those in the control group(P<0.05).The CSS scores of the observation group were significantly lower than those of the control group at 1,3,and 5 months after treatment(P<0.05).There was no significant difference in total incidence of adverse reactions of the two groups(23.26%vs 19.05%,χ^(2)=0.225,P>0.05).Conclusion Shuxuening injection combined with rosuvastatin is effective in the treatment of acute cerebral infarction.The efficacy of reducing the body’s inflammatory response,stabilizing plaque properties and restoring nerve function has a certain correlation with their combined application,an it has certain safety.