西酞普兰联合心理干预对原发性肝癌患者细胞免疫与负性情绪的影响

Effect of citalopram combined with psychological intervention on cellular immunity and negative emotion in patients with primary liver cancer

目的探讨西酞普兰联合心理干预对原发性肝癌患者细胞免疫功能以及负性情绪的影响。方法选取2018年6月至2019年8月濮阳市油田总医院收治的124例原发性肝癌患者为研究对象,根据干预方式的不同随机分为观察组和对照组各62例,对接受常规肝癌介入治疗者定为对照组,在对照组的基础上加以西普肽兰联合心理干预治疗者定为观察组。比较两组患者治疗前后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK细胞等细胞免疫指标水平;比较两组患者治疗前后癌症患者生活质量核心量表评分;比较两组患者治疗前后简易智能精神状态检测法(MMSE)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分。结果细胞免疫指标比较发现,治疗后观察组患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)以及NK细胞水平均高于对照组患者,数据比较差异有统计学意义(P<0.05)。生活质量核心量表比较发现,治疗后观察组患者躯体功能、角色功能、认知功能、情绪功能以及社会功能五个维度评分均高于对照组患者,数据差异有统计学意义(P<0.05)。两组患者负性情绪比较发现,治疗后观察组MMSE(83.17±4.47)分、HAMD(67.51±7.71)分、HAMA(60.42±5.83)分,均高于对照组患者,数据差异有统计学意义(P<0.05)。结论西酞普兰联合心理干预应用于原发性肝癌患者治疗有利于保障患者细胞免疫功能,对于调节患者情绪、改善患者心理、提高患者患者生活质量均有积极意义。

Objective To explore the effect of citalopram combined with psychological intervention on cellular immune function and negative emotion in patients with primary liver cancer.Methods Totally 124 patients with primary liver cancer who were treated in our hospital from June 2018 to August 2019 were selected as the study objects.All patients were divided into two groups according to the random number table method,62 in the observation group and 62 in the control group.The patients in the control group received routine interventional therapy for liver cancer,while the patients in the observation group were treated with ciplatan combined with psychological intervention on the basis of the control group.Before and after treatment,CD3^(+),CD4^(+),CD4^(+)/CD8^(+),NK cells and other cellular immune indexes were compared between the two groups;core quality of life scale scores of cancer patients before and after treatment were compared between the two groups;MMSE,HAMD and HAMA scores before and after treatment were compared between the two groups.Results compared with the control group,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and NK cells in the observation group were higher than those in the control group after treatment,and the difference was statistically significant(P<0.05).The core scale of quality of life showed that the scores of five dimensions of physical function,role function,cognitive function,emotional function and social function in the observation group were higher than those in the control group after treatment,and the data difference was statistically significant(P<0.05).After treatment,the scores of MMSE 83.17±4.47,HAMD 67.51±7.71 and HAMA 60.42±5.83 in the observation group were higher than those in the control group(P<0.05).Conclusion citalopram combined with psychological intervention in the treatment of patients with primary liver cancer is conducive to the protection of cellular immune function,and has positive significance in regulating patients’mood,improving patients’psychology and improving patients’quality of life.