腹腔镜手术联合新辅助化疗在结直肠癌治疗中的疗效

Efficacy of laparoscopic surgery combined with neoadjuvant chemotherapy in the treatment of colorectal cancer

目的对结直肠癌患者采取腹腔镜手术联合新辅助化疗治疗后的效果展开分析。方法66例结直肠癌患者,按照治疗方法不同分为对照组和研究组,每组33例。对照组给予传统开腹手术联合新辅助化疗,研究组给予腹腔镜手术联合新辅助化疗。对比两组患者手术指标(住院时间、术后肛门排气时间、术后下床时间、术后进食时间)、治疗后并发症发生情况、治疗后生存时间及生活质量、生活自理能力评分。结果研究组患者的住院时间为(20.1±4.0)d、术后肛门排气时间为(2.5±0.2)d、术后下床时间为(2.1 ±0.2)d、术后进食时间为(3.9±0.8)d,均显著短于对照组的(23.1±6.5)、(3.5±0.3)、(2.7±0.4)、(4.9±1.3)d,差异具有统计学意义(P<0.05)。研究组患者治疗后并发症发生率为6.1%(2/33),低于对照组的24.2%(8/33),差异具有统计学意义(P<0.05)。研究组患者的生存时间为(16.2±1.8)个月,明显长于对照组的(10.4±1.5)个月,差异具有统计学意义(P<0.05)。治疗后,研究组患者在生理、心理、社会、躯体、情感方面的生活质量评分及生活自理能力评分均显著高于对照组,差异具有统计学意义(P<0.05)。结论结直肠癌患者采取腹腔镜手术联合新辅助化疗治疗后可以有效降低传统开腹手术造成的创伤,治疗安全性较高。

Objective To analyze the effect of laparoscopic surgery combined with neoadjuvant chemotherapy in the treatment of colorectal cancer.Methods A total of 66 patients with colorectal cancer were divided into control group and research group according to different treatment methods,with 33 cases in each group.The control group received traditional open surgery combined with neoadjuvant chemotherapy,and the research group received laparoscopic surgery combined with neoadjuvant chemotherapy.The surgical indicators(hospitalization time,postoperative anal exhaust time,postoperative off-bed time and postoperative feeding time),and occurrence of complications,survival time,quality of life and self-care ability score after treatment were compared between the two groups.Results The incidence of complications after treatment 6.1%(2/33)of the research group was lower than 24.2%(8/33)of the control group,and the difference was statistically significant(P<0.05).After treatment,the incidence of complications 6.1%(2/33)of the research group was lower than 24.2%(8/33)of the control group,and the difference was statistically significant(P<0.05).The survival time of the research group was(16.2±1.8)months,which was obviously longer than(10.4±1.5)months of the control group,and the difference was statistically significant(P<0.05).The survival time of the research group was(10.4±1.5)months,which was obviously longer than(10.4±1.5)months of the control group,and the difference was statistically significant(P<0.05).After treatment,the quality of life score in physical,psychological,social,physical and emotional aspects aspect and self-care ability score of the research group were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of laparoscopic surgery and neoadjuvant chemotherapy can effectively reduce the trauma caused by traditional open surgery of patients with colorectal cancer,and the treatment is safe.