PRP与HA治疗膝早中期骨性关节炎的效果对比分析

Comparative analysis of PRP and HA in the treatment of early and middle knee osteoarthritis

目的比较自体富血小板血浆(PRP)与玻璃酸钠(HA)在早中期膝骨性关节炎患者中的临床效果。方法 95例膝关节骨性关节炎患者,依据治疗方法不同分为PRP组(47例)与HA组(48例)。PRP组采用PRP注射治疗, HA组采用HA注射治疗。比较两组治疗前后骨关节炎指数评分(WOMAC)、视觉模拟评分法(VAS)、膝关节功能主观评价表(IKDC)评分;治疗期间并发症及不良反应发生情况。结果治疗后1、3、6个月,两组患者的WOMAC、VAS评分均低于本组治疗前,且PRP组低于HA组,差异均具有统计学意义(P<0.05)。治疗后1、3、6个月,两组患者的IKDC评分均高于本组治疗前,且PRP组IKDC评分分别为(68.83±5.77)、(76.49±6.57)、(68.09±3.91)分,均高于HA组的(66.06±6.09)、(62.23±3.91)、(57.83±2.72)分,差异均具有统计学意义(P<0.05)。两组患者在治疗期间均未报告有严重并发症及不良反应发生。结论 PRP治疗膝关节骨性关节炎可有效缓解膝关节疼痛、延长膝关节使用年限、降低手术干预几率、提高患者生活质量,值得临床推广应用。

Objective To compare the clinical effect of platelet rich plasma(PRP)and hyaluronic acid(HA)in the treatment of early and middle knee osteoarthritis.Methods A total of 95 patients with knee osteoarthritis were divided into PRP group(47 cases)and HA group(48 cases)according to different treatment methods.PRP group was treated with PRP injection,and HA group was treated with HA injection.The Western Ontario and McMaster Universities osteoarthritis index(WOMAC),visual analogue scale(VAS)score,International Knee Documentation Committee(IKDC)score before and after treatment,occurrence of complications and adverse reactions during treatment were compared between the two groups.Results After 1,3 and 6 months of treatment,the WOMAC and VAS score of the two groups were lower than those before treatment,and PRP group was lower than HA group.All the difference was statistically significant(P<0.05).After 1,3 and 6 months of treatment,the IKDC score of the two groups were higher than those before treatment,and the IKDC score of PRP group were(68.83±5.77),(76.49±6.57)and(68.09±3.91)points,which were all higher than(66.06±6.09),(62.23±3.91)and(57.83±2.72)points of HA group.All the difference was statistically significant(P<0.05).No serious complications and adverse reactions were reported in the two groups.Conclusion PRP injection can effectively relieve the pain of knee osteoarthritis,extend the useful life of the knee joint,reduce the probability of surgical intervention,and improve the quality of life of patients.It is worthy of clinical promotion and application.