nm23-H1和HBME-1在乳头状甲状腺癌中的表达及其临床意义

Expression of nm 23-H1 and HBME-1 in papillary thyroid carcinoma and its clinical significance

目的分析判断在乳头状甲状腺癌肿采用nm23-H1和HBME-1的表达和临床意义。方法246例乳头甲状腺癌患者,按照随机数字表法分为对照组与观察组,各123例。对照组为未转移患者,观察组为转移患者。比较两组nm23-H1和HBME-1基因表达情况,分析nm23-H1、HBME-1表达与病理特征的相关性。结果观察组nm23-H1阳性率7.94%低于对照组的16.67%,HBME-1阳性率30.16%高于对照组的19.05%,差异均有统计学意义(P<0.05)。nm 23-H1在癌组织中的表达与肿瘤直径、淋巴结转移、临床分期呈负相关(P<0.05);HBME-1在癌组织中的表达与肿瘤直径、淋巴结转移、临床分期呈正相关(P<0.05)。结论在进行乳头状甲状腺癌治疗期间,需要检测nm23-H1和HBME-1判断阳性率,分析是否发生转移,然后进行相应治疗。

Objective To analyze the expression of nm23-H1 and HBME-1 in papillary thyroid carcinoma and its clinical significance. Methods A total of 246 patients with papillary thyroid carcinoma were divided into control group and observation group according to random numerical table, with 123 cases in each group. The control group was non-metastatic patients, and the observation group was metastatic patients. The expression of nm23-H1 and HBME-1 was compared between the two groups, and the correlation between the expression of nm23-H1 and HBME-1 and the pathological features was analyzed. Results The positive rate of nm23-H1 7.94% of the observation group was lower than 16.67% of the control group, and the positive rate of HBME-1 30.16% was higher than 19.05% of the control group. All the difference was statistically significant(P<0.05). The expression of nm23-H1 in cancer tissues was negatively correlated with tumor diameter, lymph node metastasis, and clinical stage(P<0.05);the expression of HBME-1 in cancer tissues was positively correlated with tumor diameter, lymph node metastasis, and clinical stage(P<0.05). Conclusion During the treatment of papillary thyroid cancer, it is necessary to detect nm23-H1 and HBME-1 to determine the positive rate, analyze whether metastasis occurs, and then perform corresponding treatment.