阿托伐他汀钙联合普罗布考治疗短暂性脑缺血的效果及对缺血性脑卒中的预防价值评价

The effect of atorvastatin calcium combined with probucol in the treatment of transient cerebral ischemia and its preventive value of ischemic stroke

目的评价阿托伐他汀钙联合普罗布考治疗短暂性脑缺血的效果及对缺血性脑卒中的预防价值。方法 236例短暂性脑缺血患者,随机分为参照组和试验组,各118例。参照组患者给予常规治疗,试验组给予阿托伐他汀钙联合普罗布考治疗。对比两组患者治疗效果、缺血性脑卒中发生率、血脂水平、美国国立卫生研究院卒中量表(NIHSS)评分。结果治疗后,两组患者NIHSS评分均低于治疗前,且试验组患者NIHSS评分(21.48±4.62)分低于参照组的(23.47±4.71)分,差异有统计学意义(P<0.05)。治疗后,两组患者总胆固醇、甘油三酯水平均低于治疗前,且试验组患者低于参照组,差异有统计学意义(P<0.05)。试验组患者治疗总有效率84.75%高于参照组的68.64%,缺血性脑卒中发生率11.86%低于参照组的22.03%,差异有统计学意义(P<0.05)。结论针对短暂性脑缺血采用阿托伐他汀钙联合普罗布考治疗疗效显著,其不仅可改善患者血脂水平、神经功能,亦可预防或减少缺血性脑卒中发生,值得临床推荐。

Objective To evaluate the effect of atorvastatin calcium combined with probucol in the treatment of transient cerebral ischemia and its preventive value of ischemic stroke.Methods A total of 236 patients with transient cerebral ischemia were randomly divided into reference group and experimental group,with 118 cases in each group.The reference group was treated with conventional therapy,and the experimental group was treated with atorvastatin calcium combined with probucol.The therapeutic effect,occurrence of ischemic stroke,blood lipid level,and National Institutes of Health stroke scale(NIHSS)score were compared between the two groups.Results After treatment,the NIHSS score of the two groups were lower than those before treatment,and the NIHSS score(21.48±4.62)points of the experimental group was lower than(23.47±4.71)points of the reference group.All the difference was statistically significant(P<0.05).After treatment,the total cholesterol and triglycerides of the two groups were lower than those before treatment,and the experimental group was lower than the reference group.All the difference was statistically significant(P<0.05).The total effective rate 84.75%of the experimental group was higher than 68.64%of the reference group,and incidence of ischemic stroke 11.86%was lower than 22.03%of the reference group.All the difference was statistically significant(P<0.05).Conclusion Combination of atorvastatin calcium and probucol has remarkable efficacy in the treatment of transient cerebral ischemia,which can not only improve the blood lipid and neurological function,but also prevent or reduce the occurrence of ischemic stroke.It is worthy of clinical recommendation.